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Protein Domain : IPR014749

Name  Herpesvirus US2, cytomegalovirus-type Short Name  Herpes_US2_cytomegalovirus
Type  Domain Description  Human cytomegalovirus(HHV-5) (Human herpesvirus 5) encodes several proteins that interfere with expression of major histocompatibility complex (MHC) class I and class II proteins. The unique short glycoprotein 2 (US2) is an early protein that binds to newly synthesized MHC class I heavy chains in the endoplasmic reticulum, redirecting them to the cytosol for proteasome-dependent destruction, thereby preventing their expression at the cell surface []. As a consequence, infected cells cannot be recognised by cytotoxic T lymphocytes. The US2 protein has an immunoglobulin-like beta-sandwich domain that is similar in structure to both C1- and C2-set immunoglobulin folds.

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0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:2.60.40.1200 GENE3D IPR014749

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Herpesvirus US2, cytomegalovirus-type   GO:0042288 MHC class I protein binding
Herpesvirus US2, cytomegalovirus-type   GO:0030683 evasion or tolerance by virus of host immune response
Herpesvirus US2, cytomegalovirus-type   GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
Herpesvirus US2, cytomegalovirus-type   GO:0044165 host cell endoplasmic reticulum

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Herpesvirus US2, cytomegalovirus-type   GO:0042288 MHC class I protein binding
Herpesvirus US2, cytomegalovirus-type   GO:0030683 evasion or tolerance by virus of host immune response
Herpesvirus US2, cytomegalovirus-type   GO:0046776 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
Herpesvirus US2, cytomegalovirus-type   GO:0044165 host cell endoplasmic reticulum

1 Parent Features

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain

0 Proteins