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Protein Domain : IPR000336

Name  Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain Short Name  Flavivir/Alphavir_Ig-like
Type  Domain Description  This immuniglobulin-like domain is found in polyproteins from Flavivirus and Alphavirus.Flaviruses are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Yellow fever virus, West Nile virus, Tick-borne encephalitis virus, Japanese encephalitis virus, and Dengue virus 2[]. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C (), and the envelope glycoproteins M () and E. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Class II viral fusion proteins are found in flaviviruses and alphaviruses, and are structurally distinct from class I fusion proteins from influenza-type viruses and retroviruses. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. This entry represents the Ig-like domain III, which contains a putative receptor-binding loop [].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR027287 Flavivirus glycoprotein, immunoglobulin-like domain Flavovir_Ig-like Domain

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier

1 Data Sets

Name URL
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR014412 Genome polyprotein, Flavivirus Gen_Poly_FLV Family

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain

0 Proteins