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Protein Domain : IPR018334

Name  ArsR-type transcription regulator, HTH motif Short Name  ArsR_HTH
Type  Conserved_site Description  Bacterial transcription regulatory proteins that bind DNA via a helix-turn-helix (HTH) motif can be grouped into families on the basis of sequence similarities. One such group, termed arsR, includes several proteins that appear to dissociate from DNA in the presence of metal ions: arsR, which functions as a transcriptional repressor of an arsenic resistance operon; smtB from Synechococcus sp.(strain PCC 7942), which acts as a transcriptional repressor of the smtA gene that codes for a metallothionein; cadC, a transcription regulator of the cadmium resistance (cad) operon which encodes a Cd/Pb-specific efflux ATPase [].The HTH motif is thought to be located in the central part of these proteins []. The motif is characterised by a number of well-conserved residues: at its N-terminal extremity is a cysteine residue; a second Cys is found in arsR and cadC, but not in smtA; and at the C terminus lie one or two histidines. These residues may be involved in metal-binding (Zn in smtB; metal-oxyanions such as arsenite, antimonite and arsenate for arsR; and cadmium for cadC) []. It is believed that binding of a metal ion could induce a conformational change that would prevent the protein from binding DNA [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00846 PROSITE IPR018334

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001845 HTH ArsR-type DNA-binding domain HTH_ArsR_DNA-bd_dom Domain

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
ArsR-type transcription regulator, HTH motif   GO:0003700 sequence-specific DNA binding transcription factor activity
ArsR-type transcription regulator, HTH motif   GO:0006355 regulation of transcription, DNA-templated
ArsR-type transcription regulator, HTH motif   GO:0005622 intracellular

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
ArsR-type transcription regulator, HTH motif   GO:0003700 sequence-specific DNA binding transcription factor activity
ArsR-type transcription regulator, HTH motif   GO:0006355 regulation of transcription, DNA-templated
ArsR-type transcription regulator, HTH motif   GO:0005622 intracellular

0 Parent Features

0 Proteins