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Protein Domain : IPR016481

Name  Transcription factor TFE, archaea Short Name  TF_E_archaea
Type  Family Description  Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit () and the small beta (). TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [].The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [].Archaea contain a TFIIE homolog, called TFE, which corresponds to the N-terminal half of TFIIEalpha. It appears that archaeal TFE corresponds to the minimal essential region of eukaryotic TFIIEalpha. In archaea TFE contains an N-terminal, weakly conserved, helix-turn-helix (HTH) motif within a leucine-rich region and a C-terminal zinc ribbon [, , ]. It has been proposed that the TFE/IIEalpha-type HTH domain acts as a bridging factor or adapter between the TATA box-binding protein, the polymerase, and possibly promoter DNA [].This entry represents archaeal TFE.

Publication Counts Displayer

0 Child Features

2 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR017919 Transcription factor TFE/TFIIEalpha HTH domain TFIIE/TFIIEa_HTH Domain

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF006373 PIRSF IPR016481
TIGR00373 TIGRFAMs IPR016481
MF_01909 HAMAP IPR016481

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor TFE, archaea   GO:0006355 regulation of transcription, DNA-templated

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor TFE, archaea   GO:0006355 regulation of transcription, DNA-templated

0 Parent Features

0 Proteins