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Protein Domain : IPR015621

Name  Interleukin-1 receptor family Short Name  IL-1_rcpt_fam
Type  Family Description  Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis []. Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors []. The receptors both exist in transmembrane (TM) and soluble forms: the soluble IL-1 receptor is thought to be post-translationally derived from cleavage of the extracellular portion of the membrane receptors. Both IL-1 receptors appear to be well conserved in evolution, and map to the same chromosomal location []. The receptors can both bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and interleukin-1 receptor antagonist, IL-1RA).The crystal structure of the soluble extracellular part of type-I IL1R complexed with IL1RA has been determined []. The receptor structure is characterised by three Ig-like domains, of which domains 1 and 2 are tightly linked, while domain 3 is completely separate and connected by a flexible linker.This entry represents the interleukin-1 receptor family, which includes among others: interleukin-1 receptor type 1 (IL1R1), interleukin-1 receptor type 2 (IL1R2), interleukin-1 receptor accessory protein (IL1RAP), interleukin-18 receptor 1 and interleukin-18 receptor accessory protein.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR004074 Interleukin-1 receptor type I/II IL-1_rcpt_I/II-typ Family

3 Contains

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain

1 Cross References

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Subject . Primary Identifier

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins