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Protein Domain : IPR016243

Name  Tyrosine-protein kinase, CSF-1/PDGF receptor Short Name  Tyr_kinase_CSF1/PDGF_rcpt
Type  Family Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This group represents a tyrosine-protein kinase, CSF-1/PDGF receptor type.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR027290 Platelet-derived growth factor receptor alpha PDGFRA Family
IPR027288 Platelet-derived growth factor receptor beta PGFRB Family
IPR027263 Mast/stem cell growth factor receptor SCGF_receptor Family

12 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR020635 Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site Tyr_kinase_rcpt_3_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000615 PIRSF IPR016243
PIRSF500947 PIRSF IPR016243

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

5 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0005524 ATP binding
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0006468 protein phosphorylation
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0016021 integral component of membrane

5 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0005524 ATP binding
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0006468 protein phosphorylation
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Tyrosine-protein kinase, CSF-1/PDGF receptor   GO:0016021 integral component of membrane

0 Parent Features

0 Proteins