modENCODE |  Help |  blog

Protein Domain : IPR015632

Name  T-cell surface antigen CD2 Short Name  CD2
Type  Family Description  The CD2 adhesion molecule is a cell surface protein expressed by T cells and natural killer cells. CD2's extracellular domain contains immunoglobulin-like domains that are glycosylated at two sites and can mediate homodimerisation []. Ligation of CD2 by CD58 in humans or CD48 in mice helps T cells adhere to antigen-presenting cells, and initiates signal transduction pathways that enhance signalling through the T cell receptor for antigen. CD2 knockout mice exhibit essentially normal immune function [], and it is thought that CD2 is somewhat functionally redundant with other T cell co-stimulatory receptors such as CD28 [].

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR013106 Immunoglobulin V-set domain Ig_V-set Domain
IPR008424 Immunoglobulin C2-set Ig_C2-set Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR12080:SF10 PANTHER IPR015632
PR01870 PRINTS IPR015632

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR015631 Signalling lymphocyte activation molecule family receptors SLAM_fam_rcpts Family

0 Proteins