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Protein Domain : IPR020890

Name  Transcription regulator HTH, HdfR Short Name  Tscrpt_reg_HTH_HdfR
Type  Family Description  Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI [, , , , ]. The majority of these proteins appear to be transcription activatorsand most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini.The hdfR gene encodes a LysR family protein. HdfR is able to bind to the flhDC promoter, indicating that HdfR is a transcriptional regulator for the flagellar master operon. Furthermore, the expression of the hdfR gene was shown to be negatively regulated by H-NS [].

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR005119 LysR, substrate-binding LysR_subst-bd Domain
IPR000847 Transcription regulator HTH, LysR Tscrpt_reg_HTH_LysR Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
MF_01233 HAMAP IPR020890

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription regulator HTH, HdfR   GO:0003677 DNA binding
Transcription regulator HTH, HdfR   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription regulator HTH, HdfR   GO:0045892 negative regulation of transcription, DNA-templated

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription regulator HTH, HdfR   GO:0003677 DNA binding
Transcription regulator HTH, HdfR   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription regulator HTH, HdfR   GO:0045892 negative regulation of transcription, DNA-templated

0 Parent Features

0 Proteins