modENCODE |  Help |  blog

Protein Domain : IPR009237

Name  Herpesvirus US2/US3 Short Name  Herpes_US2/US3
Type  Family Description  Unique short glycoprotein 2 (US2) and US3 are Herpesviral proteins that interfere with the expression of major histocompatibility complex (MHC) class I molecules on the surface of infected cells. US2 is an endoplasmic reticulum resident transmembrane protein that binds to newly synthesized MHC class I heavy chains in the endoplasmic reticulum, redirecting them to the cytosol for proteasome-dependent destruction, thereby preventing their expression at the cell surface []. US3 is similarly an endoplasmic reticulum resident transmembrane glycoprotein that binds MHC class I molecules and prevents their departure. The endoplasmic reticulum retention signal of the US3 protein is contained in the luminal domain of the protein [].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain

1 Cross References

Source . Name

Subject . Primary Identifier
PF05963 PFAM IPR009237

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins