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Protein Domain : IPR015726

Name  Serine/threonine protein kinase, striated muscle-specific Short Name  Ser/Thr_kin_striated_muscle-sp
Type  Family Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Eukaryotic protein kinases [, , , ]are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases.This group of genes codes for 9-kb striated preferentially expressed gene (SPEG)alpha and the 11-kb SPEGbeta found in skeletal muscle and heart. SPEGbeta encodes a 355kDa protein that contains two serine/threonine kinase domains and is homologous to proteins of the myosin light chain kinase family. At least one kinase domain is active and capable of autophosphorylation [].

Publication Counts Displayer

0 Child Features

10 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR003961 Fibronectin, type III Fibronectin_type3 Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR22964:SF9 PANTHER IPR015726

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine protein kinase, striated muscle-specific   GO:0004674 protein serine/threonine kinase activity
Serine/threonine protein kinase, striated muscle-specific   GO:0005524 ATP binding
Serine/threonine protein kinase, striated muscle-specific   GO:0006468 protein phosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine protein kinase, striated muscle-specific   GO:0004674 protein serine/threonine kinase activity
Serine/threonine protein kinase, striated muscle-specific   GO:0005524 ATP binding
Serine/threonine protein kinase, striated muscle-specific   GO:0006468 protein phosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR020675 Myosin light chain kinase-related Myosin_light_ch_kinase-rel Family

0 Proteins