modENCODE |  Help |  blog

Protein Domain : IPR020777

Name  Tyrosine-protein kinase, neurotrophic receptor Short Name  Tyr_kinase_NGF_rcpt
Type  Family Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways [].

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyr_kinase_neurotrophic_rcpt_1 Family

14 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR000483 Cysteine-rich flanking region, C-terminal Cys-rich_flank_reg_C Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR000372 Leucine-rich repeat-containing N-terminal LRR-contain_N Domain
IPR020635 Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR002011 Tyrosine-protein kinase, receptor class II, conserved site Tyr_kinase_rcpt_2_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR01939 PRINTS IPR020777

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

5 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, neurotrophic receptor   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, neurotrophic receptor   GO:0005524 ATP binding
Tyrosine-protein kinase, neurotrophic receptor   GO:0006468 protein phosphorylation
Tyrosine-protein kinase, neurotrophic receptor   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Tyrosine-protein kinase, neurotrophic receptor   GO:0005887 integral component of plasma membrane

5 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, neurotrophic receptor   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, neurotrophic receptor   GO:0005524 ATP binding
Tyrosine-protein kinase, neurotrophic receptor   GO:0006468 protein phosphorylation
Tyrosine-protein kinase, neurotrophic receptor   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Tyrosine-protein kinase, neurotrophic receptor   GO:0005887 integral component of plasma membrane

0 Parent Features

0 Proteins