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Protein Domain : IPR015459

Name	Ubiquitin-protein ligase E3 MDM2	Short Name	MDM2_E3_ligase
Type	Family	Description	MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. In addition, MDM2 acts as an E3 ubiquitin ligase responsible for the ubiquitination and subsequent degradation of p53 []. P53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. MDM2 is also known to have p53-independent functions.The core of MDM2 folds into an open bundle of four helices that is capped by two small 3-stranded beta-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 alpha-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier	Name	Short Name	Type
IPR001841	Zinc finger, RING-type	Znf_RING	Domain
IPR001876	Zinc finger, RanBP2-type	Znf_RanBP2	Domain
IPR003121	SWIB/MDM2 domain	SWIB_MDM2_domain	Domain

1 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PTHR10360:SF11	PANTHER	IPR015459

2 Data Sets

Name	URL
InterPro data set
InterPro GO Annotation data set

0 Found In

2 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Ubiquitin-protein ligase E3 MDM2		GO:0000122	negative regulation of transcription from RNA polymerase II promoter
	Ubiquitin-protein ligase E3 MDM2		GO:0016567	protein ubiquitination

2 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Ubiquitin-protein ligase E3 MDM2		GO:0000122	negative regulation of transcription from RNA polymerase II promoter
	Ubiquitin-protein ligase E3 MDM2		GO:0016567	protein ubiquitination

1 Parent Features

DB identifier	Name	Short Name	Type
IPR016495	p53 negative regulator Mdm2/Mdm4	p53_neg-reg_MDM_2/4	Family

0 Proteins

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