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Protein Domain : IPR015459

Name  Ubiquitin-protein ligase E3 MDM2 Short Name  MDM2_E3_ligase
Type  Family Description  MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. In addition, MDM2 acts as an E3 ubiquitin ligase responsible for the ubiquitination and subsequent degradation of p53 []. P53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. MDM2 is also known to have p53-independent functions.The core of MDM2 folds into an open bundle of four helices that is capped by two small 3-stranded beta-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 alpha-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR001841 Zinc finger, RING-type Znf_RING Domain
IPR001876 Zinc finger, RanBP2-type Znf_RanBP2 Domain
IPR003121 SWIB/MDM2 domain SWIB_MDM2_domain Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10360:SF11 PANTHER IPR015459

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ubiquitin-protein ligase E3 MDM2   GO:0000122 negative regulation of transcription from RNA polymerase II promoter
Ubiquitin-protein ligase E3 MDM2   GO:0016567 protein ubiquitination

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Ubiquitin-protein ligase E3 MDM2   GO:0000122 negative regulation of transcription from RNA polymerase II promoter
Ubiquitin-protein ligase E3 MDM2   GO:0016567 protein ubiquitination

1 Parent Features

DB identifier Name Short Name Type
IPR016495 p53 negative regulator Mdm2/Mdm4 p53_neg-reg_MDM_2/4 Family

0 Proteins