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Protein Domain : IPR016495

Name  p53 negative regulator Mdm2/Mdm4 Short Name  p53_neg-reg_MDM_2/4
Type  Family Description  This group represents a p53 negative regulator Mdm2/Mdm4.MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. In addition, MDM2 acts as an E3 ubiquitin ligase responsible for the ubiquitination and subsequent degradation of p53 []. P53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. MDM2 is also known to have p53-independent functions.The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-stranded beta-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 alpha-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.MDM4, also known as MDMX, is a MDM2-related protein that has also been shown to inhibit p53, although not as well as MDM2. Most studies have not been able to ascribe E3 ligase function to MDM4.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR015458 MDM4 MDM4 Family
IPR015459 Ubiquitin-protein ligase E3 MDM2 MDM2_E3_ligase Family
IPR028340 E3 ubiquitin-protein ligase Mdm2 Mdm2 Family

3 Contains

DB identifier Name Short Name Type
IPR001841 Zinc finger, RING-type Znf_RING Domain
IPR001876 Zinc finger, RanBP2-type Znf_RanBP2 Domain
IPR003121 SWIB/MDM2 domain SWIB_MDM2_domain Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF006748 PIRSF IPR016495

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
p53 negative regulator Mdm2/Mdm4   GO:0043066 negative regulation of apoptotic process
p53 negative regulator Mdm2/Mdm4   GO:0071157 negative regulation of cell cycle arrest
p53 negative regulator Mdm2/Mdm4   GO:0005634 nucleus

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
p53 negative regulator Mdm2/Mdm4   GO:0043066 negative regulation of apoptotic process
p53 negative regulator Mdm2/Mdm4   GO:0071157 negative regulation of cell cycle arrest
p53 negative regulator Mdm2/Mdm4   GO:0005634 nucleus

0 Parent Features

0 Proteins