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Protein Domain : IPR015468

Name  CD8 alpha subunit Short Name  CD8_asu
Type  Family Description  The CD8 alpha subunit is a component of the CD8 alpha-beta heterodimer and is additionally found as a homodimeric complex []. Both of these species assist in the recognition of MHC class I-peptide complexes by the alpha-beta T cell receptor (TCR). CD8 binds to constant regions of the peptide-MHC complex and augments antigen-specific interactions that are formed by the TCR []. Additionally, CD8 is directly coupled to TCR signalling by virtue of its interactions with the p56Lck kinase [], as well as other proteins. CD8 expression is limited to and one of the defining characteristics of cytolytic T cells.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain
IPR013106 Immunoglobulin V-set domain Ig_V-set Domain

1 Cross References

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Subject . Primary Identifier

1 Data Sets

Name URL
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins