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Protein Domain : IPR019888

Name  Transcription regulator AsnC-type Short Name  Tscrpt_reg_AsnC-typ
Type  Family Description  The many bacterial transcription regulation proteins which bind DNA through a'helix-turn-helix' motif can be classified into subfamilies on the basis ofsequence similarities. One such family is the AsnC/Lrp subfamily []. The Lrp family of transcriptional regulators appears to be widely distributed among bacteria andarchaea, as an important regulatory system of the amino acid metabolism and related processes []. Members of the Lrp family are small DNA-binding proteins with molecular masses of around15 kDa. Target promoters often contain anumber of binding sites that typically lack obvious inverted repeat elements, and to which binding isusually co-operative. LrpA from Pyrococcus furiosusis the first Lrp-like protein to date of which a three-dimensional structurehas been solved. In the crystal structure LrpA forms an octamer consistingof four dimers. The structure revealed that the N-terminal part of the protein consists of ahelix-turn-helix (HTH) domain, a fold generally involved in DNA binding.The C terminus of Lrp-like proteins has a beta-fold, where the two alpha-helices are located at one side of the four-stranded antiparallel beta-sheet.LrpA forms a homodimer mainly through interactions between the beta-strands of this C-terminaldomain, and an octamer through further interactions between the second alpha-helix and fourth beta-strandof the motif. Hence, the C-terminal domain of Lrp-like proteins appears tobe involved in ligand-response and activation [].

Publication Counts Displayer

0 Child Features

5 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR011008 Dimeric alpha-beta barrel Dimeric_a/b-barrel Domain
IPR019885 Transcription regulator HTH, AsnC-type, conserved site Tscrpt_reg_HTH_AsnC-type_CS Conserved_site
IPR000485 AsnC-type HTH domain AsnC-type_HTH_dom Domain
IPR019887 Transcription regulator AsnC-type, C-terminal Tscrpt_reg_AsnC-typ_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SM00344 SMART IPR019888

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription regulator AsnC-type   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription regulator AsnC-type   GO:0043565 sequence-specific DNA binding
Transcription regulator AsnC-type   GO:0006355 regulation of transcription, DNA-templated
Transcription regulator AsnC-type   GO:0005622 intracellular

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription regulator AsnC-type   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription regulator AsnC-type   GO:0043565 sequence-specific DNA binding
Transcription regulator AsnC-type   GO:0006355 regulation of transcription, DNA-templated
Transcription regulator AsnC-type   GO:0005622 intracellular

0 Parent Features

0 Proteins