modENCODE |  Help |  blog

Protein Domain : IPR019885

Name  Transcription regulator HTH, AsnC-type, conserved site Short Name  Tscrpt_reg_HTH_AsnC-type_CS
Type  Conserved_site Description  The many bacterial transcription regulation proteins which bind DNA through a'helix-turn-helix' motif can be classified into subfamilies on the basis ofsequence similarities. One such family is the AsnC/Lrp subfamily []. The Lrp family of transcriptional regulators appears to be widely distributed among bacteria andarchaea, as an important regulatory system of the amino acid metabolism and related processes []. Members of the Lrp family are small DNA-binding proteins with molecular masses of around15 kDa. Target promoters often contain anumber of binding sites that typically lack obvious inverted repeat elements, and to which binding isusually co-operative. LrpA from Pyrococcus furiosusis the first Lrp-like protein to date of which a three-dimensional structurehas been solved. In the crystal structure LrpA forms an octamer consistingof four dimers. The structure revealed that the N-terminal part of the protein consists of ahelix-turn-helix (HTH) domain, a fold generally involved in DNA binding.The C terminus of Lrp-like proteins has a beta-fold, where the two alpha-helices are located at one side of the four-stranded antiparallel beta-sheet.LrpA forms a homodimer mainly through interactions between the beta-strands of this C-terminaldomain, and an octamer through further interactions between the second alpha-helix and fourth beta-strandof the motif. Hence, the C-terminal domain of Lrp-like proteins appears tobe involved in ligand-response and activation [].This entry represents a conserved site that spans the complete helix-turn-helix motif and extends one residue downstream and one upstream of the HTH extremities.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00519 PROSITE IPR019885

1 Data Sets

Name URL
InterPro data set  

3 Found In

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR000485 AsnC-type HTH domain AsnC-type_HTH_dom Domain
IPR019888 Transcription regulator AsnC-type Tscrpt_reg_AsnC-typ Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins