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Protein Domain : IPR020900

Name  Arginine repressor, DNA-binding domain Short Name  Arg_repress_DNA-bd
Type  Domain Description  The arginine dihydrolase (AD) pathway is found in many prokaryotes and some primitive eukaryotes, an example of the latter being Giardia lamblia(Giardia intestinalis) []. The three-enzyme anaerobic pathway breaks down L-arginine to form 1 mol of ATP, carbon dioxide and ammonia. In simpler bacteria, the first enzyme, arginine deiminase, can account for up to 10% of total cell protein [].Most prokaryotic arginine deiminase pathways are under the control of a repressor gene, termed ArgR []. This is a negative regulator, and will only release the arginine deiminase operon for expression in the presence of arginine []. The crystal structure of apo-ArgR from Bacillus stearothermophilushas been determined to 2.5A by means of X-ray crystallography []. The protein exists as a hexamer of identical subunits, and is shown to have six DNA-binding domains, clustered around a central oligomeric core when bound to arginine. It predominantly interacts with A.T residues in ARG boxes. This hexameric protein binds DNA at its N terminus to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbour-joining tree, some of these paralogous sequences show long branches and differ significantly from the well-conserved C-terminal region.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF01316 PFAM IPR020900

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR001669 Arginine repressor Arg_repress Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Arginine repressor, DNA-binding domain   GO:0003700 sequence-specific DNA binding transcription factor activity
Arginine repressor, DNA-binding domain   GO:0006355 regulation of transcription, DNA-templated
Arginine repressor, DNA-binding domain   GO:0006525 arginine metabolic process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Arginine repressor, DNA-binding domain   GO:0003700 sequence-specific DNA binding transcription factor activity
Arginine repressor, DNA-binding domain   GO:0006355 regulation of transcription, DNA-templated
Arginine repressor, DNA-binding domain   GO:0006525 arginine metabolic process

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

0 Proteins