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Protein Domain : IPR009136

Name  Vascular endothelial growth factor receptor 2 (VEGFR2) Short Name  VEGFR2_rcpt
Type  Family Description  Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogen that regulates blood and lymphatic vessel development and homeostasis [, ]. EGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor beta (TGFbeta), interleukins, or platelet-derived growth factors []. VEGFs specifically interact with one or several receptor tyrosine kinases, VEGF receptors, and with distinct co-receptors such as neuropilins or heparan sulphate glycosaminoglycans. The VEGF receptor family consists of three members, VEGFR1 (FLT1), VEGFR2 (KDR/FLK1) and VEGFR3 (FLT4) []. Among these receptors, VEGFR1 binds strongest to VEGF, VEGF2 binds more weakly, and VEGFR3 shows essentially no binding, although it does bind to other members of the VEGF family. VEGF receptors have a characteristic structure, with 7 Ig-like domains in the extracellular domain and a cytoplasmic tyrosine kinase domain with a long kinase insert region. VEGF receptors are activated upon ligand-mediated dimerisation.This entry represents VEGFR2 proteins. The tyrosine kinase domain of VEGFR2 tranduces signals for endothelial cells with a greater efficacy than VEGFR1. VEGFR2 expression in adult endothelial cells appears to account for most of the mitogenic and chemotactic effects of VEGF []. At the post-receptor level, activation of endothelial cells by VEGF leads to the autophosphorylation of VEGFR2 and the subsequent tyrosine phosphorylation of numerous downstream targets.

Publication Counts Displayer

0 Child Features

12 Contains

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR020635 Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom Domain
IPR003599 Immunoglobulin subtype Ig_sub Domain
IPR008266 Tyrosine-protein kinase, active site Tyr_kinase_AS Active_site
IPR001824 Tyrosine-protein kinase, receptor class III, conserved site Tyr_kinase_rcpt_3_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR24416:SF45 PANTHER IPR009136
PR01834 PRINTS IPR009136

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

0 Found In

6 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0005021 vascular endothelial growth factor-activated receptor activity
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0005524 ATP binding
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0019838 growth factor binding
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0006468 protein phosphorylation
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0048010 vascular endothelial growth factor receptor signaling pathway
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0016021 integral component of membrane

6 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0005021 vascular endothelial growth factor-activated receptor activity
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0005524 ATP binding
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0019838 growth factor binding
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0006468 protein phosphorylation
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0048010 vascular endothelial growth factor receptor signaling pathway
Vascular endothelial growth factor receptor 2 (VEGFR2)   GO:0016021 integral component of membrane

0 Parent Features

0 Proteins