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Protein Domain : IPR000607

Name  Double-stranded RNA-specific adenosine deaminase (DRADA) Short Name  dsRNA_A_deaminase
Type  Domain Description  Double-stranded RNA-specific adenosine deaminase () converts multiple adenosines to inosinesand creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequencespecificity. DRADA has been found to modify adenosines in AU-rich regions more frequently, probablydue to the relative ease of melting A/U base pairs compared to G/C base pairs. The protein functions tomodify viral RNA genomes, and may be responsible for hypermutation of certain negative-stranded viruses.DRADA edits the mRNAs for the glutamate receptor subunits by site-selective adenosine deamination. TheDRADA repeat is also found in viral E3 proteins, which contain a double-stranded RNA-binding domain.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF02295 PFAM IPR000607
PS50139 PROFILE IPR000607
SM00550 SMART IPR000607

2 Data Sets

Name URL
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR009179 Interferon resistance/PKR inhibitor, vaccinia E3L type Interferon-R_VACE3L Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Double-stranded RNA-specific adenosine deaminase (DRADA)   GO:0003723 RNA binding
Double-stranded RNA-specific adenosine deaminase (DRADA)   GO:0003726 double-stranded RNA adenosine deaminase activity

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Double-stranded RNA-specific adenosine deaminase (DRADA)   GO:0003723 RNA binding
Double-stranded RNA-specific adenosine deaminase (DRADA)   GO:0003726 double-stranded RNA adenosine deaminase activity

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

0 Proteins