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Pathway : 89866 Signaling by EGFR

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

1 Data Sets

Name URL
Reactome data set  

91 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0015806 CG10539 S6k RPS6-p70-protein kinase FlyBase D. melanogaster
FBgn0003731 CG10079 Egfr Epidermal growth factor receptor FlyBase D. melanogaster
FBgn0003371 CG2621 sgg shaggy FlyBase D. melanogaster
FBgn0032749 CG10493 Phlpp PH domain leucine-rich repeat protein phosphatase FlyBase D. melanogaster
FBgn0016984 CG9985 sktl skittles FlyBase D. melanogaster
FBgn0028582 CG8532 lqf liquid facets FlyBase D. melanogaster
FBgn0027621 CG3400 Pfrx 6-phosphofructo-2-kinase FlyBase D. melanogaster
FBgn0014388 CG1921 sty sprouty FlyBase D. melanogaster
FBgn0026379 CG5671 Pten Pten FlyBase D. melanogaster
FBgn0040508 CG5983 ACXC ACXC FlyBase D. melanogaster
FBgn0024248 CG5686 chico chico FlyBase D. melanogaster
FBgn0014020 CG8416 Rho1 Rho1 FlyBase D. melanogaster
FBgn0010379 CG4006 Akt1 Akt1 FlyBase D. melanogaster
FBgn0000479 CG32498 dnc dunce FlyBase D. melanogaster
FBgn0035060 CG16932 Eps-15 Epidermal growth factor receptor pathway substrate clone 15 FlyBase D. melanogaster
FBgn0264815 CG44007 Pde1c FlyBase D. melanogaster
FBgn0031450 CG2903 Hrs Hepatocyte growth factor regulated tyrosine kinase substrate FlyBase D. melanogaster
FBgn0003256 CG12559 rl rolled FlyBase D. melanogaster
FBgn0032940 CG18362 Mio Mlx interactor FlyBase D. melanogaster
FBgn0259243 CG42341 Pka-R1 cAMP-dependent protein kinase R1 FlyBase D. melanogaster
FBgn0004106 CG5363 cdc2 cdc2 FlyBase D. melanogaster
FBgn0005198 CG6975 gig gigas FlyBase D. melanogaster
FBgn0004907 CG17870 14-3-3zeta 14-3-3zeta FlyBase D. melanogaster
FBgn0031006 CG8002 rictor rapamycin-insensitive companion of Tor FlyBase D. melanogaster
FBgn0033935 CG10105 Sin1 SAPK-interacting protein 1 FlyBase D. melanogaster
FBgn0003416 CG4200 sl small wing FlyBase D. melanogaster
FBgn0028978 CG5408 trbl tribbles FlyBase D. melanogaster
FBgn0004852 CG7978 Ac76E Adenylyl cyclase 76E FlyBase D. melanogaster
FBgn0014859 CG1864 Hr38 Hormone receptor-like in 38 FlyBase D. melanogaster
FBgn0001297 CG33956 kay kayak FlyBase D. melanogaster

209 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0080693 Q9VJ07 Drosophila melanogaster
FBpp0074487 Q0KHQ6 Drosophila melanogaster
FBpp0074486 Q9VWH7 Drosophila melanogaster
FBpp0073004 O44783 Drosophila melanogaster
FBpp0099930 Q2PDU2 Drosophila melanogaster
FBpp0079994 Q9VK53 Drosophila melanogaster
FBpp0099492 Q9VXU0 Drosophila melanogaster
FBpp0085583 Q7JR83 Drosophila melanogaster
FBpp0290537 Q8IRF5 Drosophila melanogaster
FBpp0087523 P81900 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0071671 Q5U0V7 Drosophila melanogaster
FBpp0074458 Q9VWJ6 Drosophila melanogaster
FBpp0076341 O46034 Drosophila melanogaster
FBpp0076342 Q9VSK2 Drosophila melanogaster
FBpp0072340 Q9W111 Drosophila melanogaster
FBpp0072339 Q8MMD2 Drosophila melanogaster
FBpp0072338 Q8MMD3 Drosophila melanogaster
FBpp0300890 E3CTP7 Drosophila melanogaster
FBpp0082682 Q8INB9 Drosophila melanogaster
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0088691 Q960X8 Drosophila melanogaster
FBpp0099540 P29310 Drosophila melanogaster
FBpp0099729 Q95RI9 Drosophila melanogaster
FBpp0099941 A8MPH9 Drosophila melanogaster
FBpp0099728 Q8INK3 Drosophila melanogaster
FBpp0099726 Q9VGM2 Drosophila melanogaster
FBpp0099725 Q8INK2 Drosophila melanogaster
FBpp0099993 Q8SXX1 Drosophila melanogaster