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Pathway : 98920 EGFR downregulation

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

12 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0003731 CG10079 Egfr Epidermal growth factor receptor FlyBase D. melanogaster
FBgn0028582 CG8532 lqf liquid facets FlyBase D. melanogaster
FBgn0014388 CG1921 sty sprouty FlyBase D. melanogaster
FBgn0035060 CG16932 Eps-15 Epidermal growth factor receptor pathway substrate clone 15 FlyBase D. melanogaster
FBgn0031450 CG2903 Hrs Hepatocyte growth factor regulated tyrosine kinase substrate FlyBase D. melanogaster
FBgn0038659 CG14296 endoA endophilin A FlyBase D. melanogaster
FBgn0020224 CG7037 Cbl Cbl FlyBase D. melanogaster
FBgn0003941 CG2960 RpL40 Ribosomal protein L40 FlyBase D. melanogaster
FBgn0003943 CG11624 Ubi-p63E Ubiquitin-63E FlyBase D. melanogaster
FBgn0027363 CG6521 Stam Signal transducing adaptor molecule FlyBase D. melanogaster
FBgn0003942 CG5271 RpS27A Ribosomal protein S27A FlyBase D. melanogaster
FBgn0027598 CG31012 cindr CIN85 and CD2AP orthologue FlyBase D. melanogaster

30 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073004 O44783 Drosophila melanogaster
FBpp0076341 O46034 Drosophila melanogaster
FBpp0076342 Q9VSK2 Drosophila melanogaster
FBpp0072340 Q9W111 Drosophila melanogaster
FBpp0072339 Q8MMD2 Drosophila melanogaster
FBpp0072338 Q8MMD3 Drosophila melanogaster
FBpp0300890 E3CTP7 Drosophila melanogaster
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0088691 Q960X8 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0083113 Q8T390 Drosophila melanogaster
FBpp0079732 Q9XTL2 Drosophila melanogaster
FBpp0076509 Q9VS85 Drosophila melanogaster
FBpp0076508 Q7KU90 Drosophila melanogaster
FBpp0089150 Q7KU93 Drosophila melanogaster
FBpp0085066 Q9VA36 Drosophila melanogaster
FBpp0085068 Q9Y154 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0085069 Q9VA35 Drosophila melanogaster
FBpp0085067 Q86PF3 Drosophila melanogaster
FBpp0111854 A8JNM3 Drosophila melanogaster
EGFR_DROME P04412 Drosophila melanogaster
Q8WQ61_DROME Q8WQ61 Drosophila melanogaster
P91683_DROME P91683 Drosophila melanogaster
B3DMQ0_DROME B3DMQ0 Drosophila melanogaster
Q7YU85_DROME Q7YU85 Drosophila melanogaster
Q9U741_DROME Q9U741 Drosophila melanogaster
Q8T0I6_DROME Q8T0I6 Drosophila melanogaster
Q9U740 Drosophila melanogaster
Q19RV3 Drosophila melanogaster