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Pathway : 30635 Insulin receptor signalling cascade

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

1 Data Sets

Name URL
Reactome data set  

61 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0261592 CG10944 RpS6 Ribosomal protein S6 FlyBase D. melanogaster
FBgn0015806 CG10539 S6k RPS6-p70-protein kinase FlyBase D. melanogaster
FBgn0023169 CG3051 SNF1A SNF1A/AMP-activated protein kinase FlyBase D. melanogaster
FBgn0036046 CG8167 Ilp2 Insulin-like peptide 2 FlyBase D. melanogaster
FBgn0044051 CG14173 Ilp1 Insulin-like peptide 1 FlyBase D. melanogaster
FBgn0026379 CG5671 Pten Pten FlyBase D. melanogaster
FBgn0024248 CG5686 chico chico FlyBase D. melanogaster
FBgn0017572 CG4083 Mo25 Mo25 FlyBase D. melanogaster
FBgn0010379 CG4006 Akt1 Akt1 FlyBase D. melanogaster
FBgn0041191 CG1081 Rheb Ras homolog enriched in brain ortholog (H. sapiens) FlyBase D. melanogaster
FBgn0003256 CG12559 rl rolled FlyBase D. melanogaster
FBgn0032940 CG18362 Mio Mlx interactor FlyBase D. melanogaster
FBgn0004106 CG5363 cdc2 cdc2 FlyBase D. melanogaster
FBgn0005198 CG6975 gig gigas FlyBase D. melanogaster
FBgn0020660 CG10837 eIF-4B Eukaryotic initiation factor 4B FlyBase D. melanogaster
FBgn0004907 CG17870 14-3-3zeta 14-3-3zeta FlyBase D. melanogaster
FBgn0028978 CG5408 trbl tribbles FlyBase D. melanogaster
FBgn0015218 CG4035 eIF-4E Eukaryotic initiation factor 4E FlyBase D. melanogaster
FBgn0265089 CG8023 eIF4E-3 eukaryotic translation initiation factor 4E-3 FlyBase D. melanogaster
FBgn0044047 CG14049 Ilp6 Insulin-like peptide 6 FlyBase D. melanogaster
FBgn0261560 CG8846 Thor Thor FlyBase D. melanogaster
FBgn0001297 CG33956 kay kayak FlyBase D. melanogaster
FBgn0260634 CG10192 eIF4G2 eukaryotic translation initiation factor 4G2 FlyBase D. melanogaster
FBgn0038197 CG3143 foxo forkhead box, sub-group O FlyBase D. melanogaster
FBgn0005638 CG4354 slbo slow border cells FlyBase D. melanogaster
FBgn0020386 CG1210 Pdk1 Phosphoinositide-dependent kinase 1 FlyBase D. melanogaster
FBgn0086361 CG1906 alph alphabet FlyBase D. melanogaster
FBgn0010269 CG15793 Dsor1 Downstream of raf1 FlyBase D. melanogaster
FBgn0264357 CG17299 SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit FlyBase D. melanogaster
FBgn0038167 CG9374 lkb1 lkb1 FlyBase D. melanogaster

125 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0070390 Q9W4Z4 Drosophila melanogaster
FBpp0076057 Q9VT50 Drosophila melanogaster
FBpp0075117 P91891 Drosophila melanogaster
FBpp0076424 Q9VSG1 Drosophila melanogaster
FBpp0290800 A1A703 Drosophila melanogaster
FBpp0290703 Q8T9L5 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0076102 Q9VT52 Drosophila melanogaster
FBpp0082682 Q8INB9 Drosophila melanogaster
FBpp0070552 Q9W4Q9 Drosophila melanogaster
FBpp0099540 P29310 Drosophila melanogaster
FBpp0099941 A8MPH9 Drosophila melanogaster
FBpp0084441 Q9VB98 Drosophila melanogaster
FBpp0290804 Q9VDD2 Drosophila melanogaster
FBpp0070208 O18645 Drosophila melanogaster
FBpp0110403 P83098 Drosophila melanogaster
FBpp0290802 Q8SXT8 Drosophila melanogaster
FBpp0083931 Q9VCC9 Drosophila melanogaster
FBpp0110237 Q0KI34 Drosophila melanogaster
FBpp0077213 Q9XZ56 Drosophila melanogaster
FBpp0070385 P11346 Drosophila melanogaster
FBpp0079641 P23572 Drosophila melanogaster
FBpp0112426 P40417 Drosophila melanogaster
FBpp0076220 P48598 Drosophila melanogaster
FBpp0088182 Q9XYM0 Drosophila melanogaster
FBpp0081600 P08646 Drosophila melanogaster
FBpp0083348 P91634 Drosophila melanogaster
FBpp0072366 Q9W0V1 Drosophila melanogaster
FBpp0070559 P48555 Drosophila melanogaster