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Pathway : 134604 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

18 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0005632 CG1945 faf fat facets FlyBase D. melanogaster
FBgn0011655 CG1775 Med Medea FlyBase D. melanogaster
FBgn0033749 CG8819 achi achintya FlyBase D. melanogaster
FBgn0010247 CG40411 Parp Poly-(ADP-ribose) polymerase FlyBase D. melanogaster
FBgn0025800 CG2262 Smox Smad on X FlyBase D. melanogaster
FBgn0265523 CG4013 Smr Smrter FlyBase D. melanogaster
FBgn0086361 CG1906 alph alphabet FlyBase D. melanogaster
FBgn0023097 CG5206 bon bonus FlyBase D. melanogaster
FBgn0029006 CG4943 lack lethal with a checkpoint kinase FlyBase D. melanogaster
FBgn0085450 CG34421 Snoo Sno oncogene FlyBase D. melanogaster
FBgn0259174 CG42279 Nedd4 Nedd4 FlyBase D. melanogaster
FBgn0003941 CG2960 RpL40 Ribosomal protein L40 FlyBase D. melanogaster
FBgn0033748 CG8821 vis vismay FlyBase D. melanogaster
FBgn0011217 CG7425 eff effete FlyBase D. melanogaster
FBgn0015805 CG7471 Rpd3 Rpd3 FlyBase D. melanogaster
FBgn0003943 CG11624 Ubi-p63E Ubiquitin-63E FlyBase D. melanogaster
FBgn0003942 CG5271 RpS27A Ribosomal protein S27A FlyBase D. melanogaster
FBgn0037944 CG6923 CG6923 FlyBase D. melanogaster

54 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087053 A1Z916 Drosophila melanogaster
FBpp0087054 Q7JR08 Drosophila melanogaster
FBpp0305906 Q9VYK0 Drosophila melanogaster
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0081908 Q9VGI6 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0085176 O62609 Drosophila melanogaster
FBpp0085177 Q8IMG6 Drosophila melanogaster
FBpp0085202 P55824 Drosophila melanogaster
FBpp0083320 Q9VDK5 Drosophila melanogaster
FBpp0087055 Q7K380 Drosophila melanogaster
FBpp0087056 A1Z913 Drosophila melanogaster
FBpp0082477 P25867 Drosophila melanogaster
FBpp0086011 Q9V853 Drosophila melanogaster
FBpp0071140 O96660 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0073173 Q94517 Drosophila melanogaster
FBpp0111629 Q00G30 Drosophila melanogaster
FBpp0084810 Q961C5 Drosophila melanogaster
FBpp0084808 Q9VAK1 Drosophila melanogaster
FBpp0084809 Q8IMK7 Drosophila melanogaster
FBpp0112608 P35875 Drosophila melanogaster
FBpp0289746 Q9VVI3 Drosophila melanogaster
FBpp0289844 A8WHL4 Drosophila melanogaster
O76259_DROME O76259 Drosophila melanogaster
O77069_DROME O77069 Drosophila melanogaster
Q7KPL1_DROME Q7KPL1 Drosophila melanogaster
O61458_DROME O61458 Drosophila melanogaster
Q9U3Y7_DROME Q9U3Y7 Drosophila melanogaster
A0PDV0_DROME A0PDV0 Drosophila melanogaster