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Pathway : 145763 Downregulation of ERBB4 signaling

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

6 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0003731 CG10079 Egfr Epidermal growth factor receptor FlyBase D. melanogaster
FBgn0259174 CG42279 Nedd4 Nedd4 FlyBase D. melanogaster
FBgn0003941 CG2960 RpL40 Ribosomal protein L40 FlyBase D. melanogaster
FBgn0003943 CG11624 Ubi-p63E Ubiquitin-63E FlyBase D. melanogaster
FBgn0003942 CG5271 RpS27A Ribosomal protein S27A FlyBase D. melanogaster
FBgn0003557 CG4244 Su(dx) Suppressor of deltex FlyBase D. melanogaster

6 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0077495 Q9Y0H4 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0289746 Q9VVI3 Drosophila melanogaster
EGFR_DROME P04412 Drosophila melanogaster