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Pathway : 149593 Constitutive PI3K/AKT Signaling in Cancer

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

14 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0015806 CG10539 S6k RPS6-p70-protein kinase FlyBase D. melanogaster
FBgn0003371 CG2621 sgg shaggy FlyBase D. melanogaster
FBgn0026379 CG5671 Pten Pten FlyBase D. melanogaster
FBgn0010379 CG4006 Akt1 Akt1 FlyBase D. melanogaster
FBgn0005198 CG6975 gig gigas FlyBase D. melanogaster
FBgn0031006 CG8002 rictor rapamycin-insensitive companion of Tor FlyBase D. melanogaster
FBgn0033935 CG10105 Sin1 SAPK-interacting protein 1 FlyBase D. melanogaster
FBgn0014859 CG1864 Hr38 Hormone receptor-like in 38 FlyBase D. melanogaster
FBgn0038197 CG3143 foxo forkhead box, sub-group O FlyBase D. melanogaster
FBgn0020386 CG1210 Pdk1 Phosphoinositide-dependent kinase 1 FlyBase D. melanogaster
FBgn0264691 CG3004 Lst8 FlyBase D. melanogaster
FBgn0021796 CG5092 Tor Target of rapamycin FlyBase D. melanogaster
FBgn0024222 CG4201 ird5 immune response deficient 5 FlyBase D. melanogaster
FBgn0265784 CG6103 CrebB Cyclic-AMP response element binding protein B FlyBase D. melanogaster

30 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0074458 Q9VWJ6 Drosophila melanogaster
FBpp0082682 Q8INB9 Drosophila melanogaster
FBpp0072366 Q9W0V1 Drosophila melanogaster
FBpp0070449 P18431 Drosophila melanogaster
FBpp0074588 Q9VW83 Drosophila melanogaster
FBpp0074326 Q9VWW0 Drosophila melanogaster
FBpp0088843 Q7KMQ6 Drosophila melanogaster
FBpp0088844 Q9V3L4 Drosophila melanogaster
FBpp0088841 Q9Y0B6 Drosophila melanogaster
FBpp0086616 Q9V719 Drosophila melanogaster
FBpp0071303 Q9W328 Drosophila melanogaster
FBpp0089343 Q95V55 Drosophila melanogaster
HR38_DROME P49869 Drosophila melanogaster
IKKB_DROME Q9VEZ5 Drosophila melanogaster
Q7YU91_DROME Q7YU91 Drosophila melanogaster
Q9U470_DROME Q9U470 Drosophila melanogaster
Q9U9B0_DROME Q9U9B0 Drosophila melanogaster
Q9Y0B5_DROME Q9Y0B5 Drosophila melanogaster
P91656_DROME P91656 Drosophila melanogaster
Q8SWT5_DROME Q8SWT5 Drosophila melanogaster
Q7K0T0 Drosophila melanogaster
Q7KJN5 Drosophila melanogaster
Q7KJN6 Drosophila melanogaster
H1ZYC9 Drosophila melanogaster
H1ZYC5 Drosophila melanogaster
H1ZYE3 Drosophila melanogaster
H1ZYD2 Drosophila melanogaster
H1ZYD3 Drosophila melanogaster