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Pathway : 128220 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

8 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0025574 CG5212 Pli Pellino FlyBase D. melanogaster
FBgn0265464 CG10961 Traf6 TNF-receptor-associated factor 6 FlyBase D. melanogaster
FBgn0010441 CG5974 pll pelle FlyBase D. melanogaster
FBgn0024222 CG4201 ird5 immune response deficient 5 FlyBase D. melanogaster
FBgn0035601 CG10640 Uev1A Uev1A FlyBase D. melanogaster
FBgn0041205 CG16910 key kenny FlyBase D. melanogaster
FBgn0000173 CG18319 ben bendless FlyBase D. melanogaster
FBgn0028913 CG3473 CG3473 FlyBase D. melanogaster

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0298297 P35128 Drosophila melanogaster
FBpp0083913 O77237 Drosophila melanogaster
FBpp0076859 Q9VRL1 Drosophila melanogaster
FBpp0076860 Q8IQ53 Drosophila melanogaster
FBpp0084549 Q05652 Drosophila melanogaster
FBpp0080227 Q9VJS5 Drosophila melanogaster
FBpp0071136 Q9W3I9 Drosophila melanogaster
IKKB_DROME Q9VEZ5 Drosophila melanogaster
NEMO_DROME Q9GYV5 Drosophila melanogaster
Q9UAC4_DROME Q9UAC4 Drosophila melanogaster
Q9XYQ9_DROME Q9XYQ9 Drosophila melanogaster
Q8IGH9 Drosophila melanogaster