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Pathway : 128412 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

1 Data Sets

Name URL
Reactome data set  

7 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0265464 CG10961 Traf6 TNF-receptor-associated factor 6 FlyBase D. melanogaster
FBgn0010441 CG5974 pll pelle FlyBase D. melanogaster
FBgn0003941 CG2960 RpL40 Ribosomal protein L40 FlyBase D. melanogaster
FBgn0086358 CG7417 Tab2 TAK1-associated binding protein 2 FlyBase D. melanogaster
FBgn0026323 CG18492 Tak1 TGF-beta activated kinase 1 FlyBase D. melanogaster
FBgn0003943 CG11624 Ubi-p63E Ubiquitin-63E FlyBase D. melanogaster
FBgn0003942 CG5271 RpS27A Ribosomal protein S27A FlyBase D. melanogaster

11 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085704 Q6NQZ7 Drosophila melanogaster
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0077011 Q9V3Q6 Drosophila melanogaster
FBpp0084549 Q05652 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0071136 Q9W3I9 Drosophila melanogaster
Q9UAC4_DROME Q9UAC4 Drosophila melanogaster
Q9XYQ9_DROME Q9XYQ9 Drosophila melanogaster
Q4TZQ4_DROME Q4TZQ4 Drosophila melanogaster
Q9NFL3_DROME Q9NFL3 Drosophila melanogaster