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Pathway : 87442 activated TAK1 mediates p38 MAPK activation

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

1 Data Sets

Name URL
Reactome data set  

10 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0024846 CG7393 p38b p38b FlyBase D. melanogaster
FBgn0015765 CG5475 Mpk2 Mpk2 FlyBase D. melanogaster
FBgn0265464 CG10961 Traf6 TNF-receptor-associated factor 6 FlyBase D. melanogaster
FBgn0010441 CG5974 pll pelle FlyBase D. melanogaster
FBgn0024222 CG4201 ird5 immune response deficient 5 FlyBase D. melanogaster
FBgn0086358 CG7417 Tab2 TAK1-associated binding protein 2 FlyBase D. melanogaster
FBgn0261524 CG12244 lic licorne FlyBase D. melanogaster
FBgn0026323 CG18492 Tak1 TGF-beta activated kinase 1 FlyBase D. melanogaster
FBgn0013987 CG3086 MAPk-Ak2 MAP kinase activated protein-kinase-2 FlyBase D. melanogaster
FBgn0041205 CG16910 key kenny FlyBase D. melanogaster

15 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085704 Q6NQZ7 Drosophila melanogaster
FBpp0070802 P49071 Drosophila melanogaster
FBpp0073551 O62602 Drosophila melanogaster
FBpp0077011 Q9V3Q6 Drosophila melanogaster
FBpp0083965 O62618 Drosophila melanogaster
FBpp0084549 Q05652 Drosophila melanogaster
FBpp0080111 O61443 Drosophila melanogaster
FBpp0071136 Q9W3I9 Drosophila melanogaster
IKKB_DROME Q9VEZ5 Drosophila melanogaster
NEMO_DROME Q9GYV5 Drosophila melanogaster
Q9UAC4_DROME Q9UAC4 Drosophila melanogaster
Q9XYQ9_DROME Q9XYQ9 Drosophila melanogaster
Q9U983_DROME Q9U983 Drosophila melanogaster
Q4TZQ4_DROME Q4TZQ4 Drosophila melanogaster
Q9NFL3_DROME Q9NFL3 Drosophila melanogaster