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Pathway : 113278 TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Curated  false
Description: This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.


1 Data Sets

Name URL
Reactome data set  

16 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0023423 CG3412 slmb supernumerary limbs FlyBase D. melanogaster
FBgn0260632 CG6667 dl dorsal FlyBase D. melanogaster
FBgn0011274 CG6794 Dif Dorsal-related immunity factor FlyBase D. melanogaster
FBgn0026176 CG8881 skpB skpB FlyBase D. melanogaster
FBgn0000250 CG5848 cact cactus FlyBase D. melanogaster
FBgn0265464 CG10961 Traf6 TNF-receptor-associated factor 6 FlyBase D. melanogaster
FBgn0015509 CG1877 lin19 lin-19-like FlyBase D. melanogaster
FBgn0010441 CG5974 pll pelle FlyBase D. melanogaster
FBgn0033402 CG2078 Myd88 Myd88 FlyBase D. melanogaster
FBgn0024222 CG4201 ird5 immune response deficient 5 FlyBase D. melanogaster
FBgn0014018 CG11992 Rel Relish FlyBase D. melanogaster
FBgn0025638 CG16982 Roc1a Roc1a FlyBase D. melanogaster
FBgn0086358 CG7417 Tab2 TAK1-associated binding protein 2 FlyBase D. melanogaster
FBgn0026323 CG18492 Tak1 TGF-beta activated kinase 1 FlyBase D. melanogaster
FBgn0041205 CG16910 key kenny FlyBase D. melanogaster
FBgn0002774 CG11680 mle maleless FlyBase D. melanogaster

23 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085704 Q6NQZ7 Drosophila melanogaster
FBpp0290793 P98149 Drosophila melanogaster
FBpp0080560 P15330 Drosophila melanogaster
FBpp0077011 Q9V3Q6 Drosophila melanogaster
FBpp0087921 Q24311 Drosophila melanogaster
FBpp0088375 Q94527 Drosophila melanogaster
FBpp0080402 Q03017 Drosophila melanogaster
FBpp0085367 P24785 Drosophila melanogaster
FBpp0087679 Q7K105 Drosophila melanogaster
FBpp0084549 Q05652 Drosophila melanogaster
FBpp0087127 Q7KJ69 Drosophila melanogaster
FBpp0083434 Q9VDE3 Drosophila melanogaster
FBpp0071136 Q9W3I9 Drosophila melanogaster
FBpp0070117 Q9W5E1 Drosophila melanogaster
IKKB_DROME Q9VEZ5 Drosophila melanogaster
NEMO_DROME Q9GYV5 Drosophila melanogaster
Q9UAC4_DROME Q9UAC4 Drosophila melanogaster
O44382_DROME O44382 Drosophila melanogaster
Q9XYQ9_DROME Q9XYQ9 Drosophila melanogaster
C4XVM1_DROME C4XVM1 Drosophila melanogaster
Q4TZQ4_DROME Q4TZQ4 Drosophila melanogaster
Q9NFL3_DROME Q9NFL3 Drosophila melanogaster
O77430 Drosophila melanogaster