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Pathway : 6313 Insulin receptor mediated signaling

Curated  false
Description: Reviewed: Tatar, M, 2004-05-12 07:00:00The insulin/IGF-like signaling (IIS) and TOR pathways are responsible for conveying nutrient signals and regulating growth in Drosophila. Activation of the IIS pathway occurs when insulin-like peptides bind the insulin receptor. Activation of the TOR signaling pathway occurs in the presence of amino acids via an unknown mechanism.

Together, these pathways coordinate cell-autonomous and non cell-autonomous growth responses to nutrients. The exact way these two signaling pathways are coordinated and their outputs balanced are not understood.Authored: Broughton, S, Gianakou, M, Leevers, SJ, Partridge, L, Piper, M, Jassal, B, 2005-06-14 11:07:15


1 Data Sets

Name URL
Reactome data set  

82 Genes

DB identifier Secondary Identifier Symbol Name Source Organism
FBgn0261592 CG10944 RpS6 Ribosomal protein S6 FlyBase D. melanogaster
FBgn0015806 CG10539 S6k RPS6-p70-protein kinase FlyBase D. melanogaster
FBgn0023169 CG3051 SNF1A SNF1A/AMP-activated protein kinase FlyBase D. melanogaster
FBgn0036046 CG8167 Ilp2 Insulin-like peptide 2 FlyBase D. melanogaster
FBgn0044051 CG14173 Ilp1 Insulin-like peptide 1 FlyBase D. melanogaster
FBgn0263598 CG3762 Vha68-2 Vacuolar H[+] ATPase 68 kDa subunit 2 FlyBase D. melanogaster
FBgn0026379 CG5671 Pten Pten FlyBase D. melanogaster
FBgn0024248 CG5686 chico chico FlyBase D. melanogaster
FBgn0017572 CG4083 Mo25 Mo25 FlyBase D. melanogaster
FBgn0010379 CG4006 Akt1 Akt1 FlyBase D. melanogaster
FBgn0262511 CG8048 Vha44 Vacuolar H[+] ATPase 44kD subunit FlyBase D. melanogaster
FBgn0041191 CG1081 Rheb Ras homolog enriched in brain ortholog (H. sapiens) FlyBase D. melanogaster
FBgn0003256 CG12559 rl rolled FlyBase D. melanogaster
FBgn0032940 CG18362 Mio Mlx interactor FlyBase D. melanogaster
FBgn0004106 CG5363 cdc2 cdc2 FlyBase D. melanogaster
FBgn0005198 CG6975 gig gigas FlyBase D. melanogaster
FBgn0020660 CG10837 eIF-4B Eukaryotic initiation factor 4B FlyBase D. melanogaster
FBgn0004907 CG17870 14-3-3zeta 14-3-3zeta FlyBase D. melanogaster
FBgn0028978 CG5408 trbl tribbles FlyBase D. melanogaster
FBgn0015218 CG4035 eIF-4E Eukaryotic initiation factor 4E FlyBase D. melanogaster
FBgn0265089 CG8023 eIF4E-3 eukaryotic translation initiation factor 4E-3 FlyBase D. melanogaster
FBgn0005671 CG17369 Vha55 Vacuolar H[+]-ATPase 55kD subunit FlyBase D. melanogaster
FBgn0022097 CG8186 Vha36-1 Vacuolar H[+] ATPase 36kD subunit 1 FlyBase D. melanogaster
FBgn0044047 CG14049 Ilp6 Insulin-like peptide 6 FlyBase D. melanogaster
FBgn0262512 CG8210 Vha14-1 Vacuolar H[+] ATPase 14kD subunit 1 FlyBase D. melanogaster
FBgn0261560 CG8846 Thor Thor FlyBase D. melanogaster
FBgn0262736 CG3161 Vha16-1 Vacuolar H[+] ATPase 16kD subunit 1 FlyBase D. melanogaster
FBgn0001297 CG33956 kay kayak FlyBase D. melanogaster
FBgn0260634 CG10192 eIF4G2 eukaryotic translation initiation factor 4G2 FlyBase D. melanogaster
FBgn0038197 CG3143 foxo forkhead box, sub-group O FlyBase D. melanogaster

152 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0070390 Q9W4Z4 Drosophila melanogaster
FBpp0076057 Q9VT50 Drosophila melanogaster
FBpp0075822 Q9VTI6 Drosophila melanogaster
FBpp0075117 P91891 Drosophila melanogaster
FBpp0076424 Q9VSG1 Drosophila melanogaster
FBpp0290800 A1A703 Drosophila melanogaster
FBpp0079999 Q27331 Drosophila melanogaster
FBpp0290703 Q8T9L5 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0076102 Q9VT52 Drosophila melanogaster
FBpp0082682 Q8INB9 Drosophila melanogaster
FBpp0070552 Q9W4Q9 Drosophila melanogaster
FBpp0075821 Q8IQG3 Drosophila melanogaster
FBpp0099540 P29310 Drosophila melanogaster
FBpp0099941 A8MPH9 Drosophila melanogaster
FBpp0300391 Q9VFE3 Drosophila melanogaster
FBpp0078234 Q9VNL3 Drosophila melanogaster
FBpp0084441 Q9VB98 Drosophila melanogaster
FBpp0290804 Q9VDD2 Drosophila melanogaster
FBpp0070208 O18645 Drosophila melanogaster
FBpp0110403 P83098 Drosophila melanogaster
FBpp0290802 Q8SXT8 Drosophila melanogaster
FBpp0083931 Q9VCC9 Drosophila melanogaster
FBpp0110237 Q0KI34 Drosophila melanogaster
FBpp0077213 Q9XZ56 Drosophila melanogaster
FBpp0070385 P11346 Drosophila melanogaster
FBpp0079641 P23572 Drosophila melanogaster
FBpp0112426 P40417 Drosophila melanogaster
FBpp0080494 Q9V3J1 Drosophila melanogaster