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Protein Domain : IPR001867

Name  Signal transduction response regulator, C-terminal Short Name  Sig_transdc_resp-reg_C
Type  Domain Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents a domain that is almost always found associated with the response regulator receiver domain (see ). It may play a role in DNA binding [].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00486 PFAM IPR001867
SM00862 SMART IPR001867

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR016032 Signal transduction response regulator, C-terminal effector Sig_transdc_resp-reg_C-effctor Domain
IPR022305 Sortase system response regulator Response_regulator Family
IPR011879 Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB Sig_transdc_resp-reg_PhoB Family
IPR006291 Signal transduction response regulator, heavy metal response Sig_transdc_resp-reg_metal Family

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, C-terminal   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, C-terminal   GO:0003677 DNA binding
Signal transduction response regulator, C-terminal   GO:0000160 phosphorelay signal transduction system
Signal transduction response regulator, C-terminal   GO:0006355 regulation of transcription, DNA-templated

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, C-terminal   GO:0000156 phosphorelay response regulator activity
Signal transduction response regulator, C-terminal   GO:0003677 DNA binding
Signal transduction response regulator, C-terminal   GO:0000160 phosphorelay signal transduction system
Signal transduction response regulator, C-terminal   GO:0006355 regulation of transcription, DNA-templated

0 Parent Features

1 Proteins

DB identifier Primary Accession
Organism . Name
E3NVS3_CAERE E3NVS3 Caenorhabditis remanei