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Protein Domain : IPR000524

Name  Transcription regulator HTH, GntR Short Name  Tscrpt_reg_HTH_GntR
Type  Domain Description  Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilisrepressor of the gluconate operon []. Family members include GntR, HutC, KorA, NtaR, FadR, ExuR, FarR, DgoR and PhnF. The crystal structure of the FadR protein has been determined []. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector-binding or oligomerisation domain at the C terminus (). The DNA-binding domain is well conserved in structure for the whole of the GntR family, consisting of a 3-helical bundle core with a small beta-sheet (wing); the GntR winged helix structure is similar to that found in several other transcriptional regulator families. The regions outside the DNA-binding domain are more variable and are consequently used to define GntR subfamilies []. This entry represents the N-terminal DNA-binding domain of the GntR family.

Publication Counts Displayer

0 Child Features

0 Contains

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00392 PFAM IPR000524
PR00035 PRINTS IPR000524
PS50949 PROFILE IPR000524
SM00345 SMART IPR000524

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

6 Found In

DB identifier Name Short Name Type
IPR017723 Transcription regulator, 2-aminoethylphosphonate utilisation-associated Tscrpt_reg_AEP_util-assoc Family
IPR017722 Transcription regulator PhnR Tscrpt_reg_PhnR Family
IPR014178 Fatty acid response transcription factor FadR FA-response_TF_FadR Family
IPR012702 Phosphonate C-P lyase system, transcriptional regulator PhnF CP_lyase_PhnF Family
IPR012770 Trehalose transcription repressor Trehalos_R_Gpos Family
IPR010248 Histidine utilization repressor His_ut_repres Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription regulator HTH, GntR   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription regulator HTH, GntR   GO:0006355 regulation of transcription, DNA-templated

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription regulator HTH, GntR   GO:0003700 sequence-specific DNA binding transcription factor activity
Transcription regulator HTH, GntR   GO:0006355 regulation of transcription, DNA-templated

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

2 Proteins

DB identifier Primary Accession
Organism . Name
K7IG18_CAEJA K7IG18 Caenorhabditis japonica
E3NX56_CAERE E3NX56 Caenorhabditis remanei