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Protein Domain : IPR016032

Name  Signal transduction response regulator, C-terminal effector Short Name  Sig_transdc_resp-reg_C-effctor
Type  Domain Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents a structural domain usually found at the C-terminal of bipartite response regulators. These proteins are known to bind to DNA and RNA polymerases, and their N-terminal receiver domain belongs to the CheY family. The C-terminal effector domain consists of a 3-helical bundle in an up-an-down arrangement with a right-handed twist. This domain occurs in:PhoB-like proteins, which includes PhoB [], OmpR [], and DrrB []; these proteins contain a 4-stranded meander beta-sheet in the N-terminal extension.GerE-like proteins from the LuxR/UhpA family of proteins, which includes GerE [], TraR (quorum-sensing) [], NarL (nitrate/nitrite response regulator) [], and RcsB transcriptional regulator []; these proteins contain an additional fourth helix in the C-terminal extension.Spo0A proteins [], which are elaborated with additional helices.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR000792 Transcription regulator LuxR, C-terminal Tscrpt_reg_LuxR_C Domain
IPR014879 Sporulation initiation factor Spo0A, C-terminal Spo0A_C Domain

1 Contains

DB identifier Name Short Name Type
IPR001867 Signal transduction response regulator, C-terminal Sig_transdc_resp-reg_C Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF46894 SSF IPR016032

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR019941 Transcription regulator LuxR, chaperone HchA-associated Tscrpt_reg_LuxR_HchA-assoc Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, C-terminal effector   GO:0003677 DNA binding
Signal transduction response regulator, C-terminal effector   GO:0006355 regulation of transcription, DNA-templated

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Signal transduction response regulator, C-terminal effector   GO:0003677 DNA binding
Signal transduction response regulator, C-terminal effector   GO:0006355 regulation of transcription, DNA-templated

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

11 Proteins

DB identifier Primary Accession
Organism . Name
K7HKV0_CAEJA K7HKV0 Caenorhabditis japonica
K7HUM2_CAEJA K7HUM2 Caenorhabditis japonica
K7HUM3_CAEJA K7HUM3 Caenorhabditis japonica
K7HE06_CAEJA K7HE06 Caenorhabditis japonica
K7HGI7_CAEJA K7HGI7 Caenorhabditis japonica
K7GYF4_CAEJA K7GYF4 Caenorhabditis japonica
K7HTE9_CAEJA K7HTE9 Caenorhabditis japonica
K7HWW3_CAEJA K7HWW3 Caenorhabditis japonica
K7IGE0_CAEJA K7IGE0 Caenorhabditis japonica
E3NPA9_CAERE E3NPA9 Caenorhabditis remanei
E3NVS3_CAERE E3NVS3 Caenorhabditis remanei