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Protein Domain : IPR021184

Name  Tumour necrosis factor, conserved site Short Name  TNF_CS
Type  Conserved_site Description  Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [, , ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [, ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine []. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers []. Both the mature protein anda partially-processed form of the hormone are secreted after cleavage of the propeptide [].There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors. The following cytokines can be grouped into a family on the basis of sequence, functional, and structural similarities [, , ]: Tumor Necrosis Factor (TNF) (also known as cachectin or TNF-alpha) [, ]is a cytokine which has a wide variety of functions. It can cause cytolysis of certain tumor cell lines; it is involved in the induction of cachexia; it is a potent pyrogen, causing fever by direct action or by stimulation of interleukin-1 secretion; finally, it can stimulate cell proliferation and induce cell differentiation under certain conditions.Lymphotoxin-alpha (LT-alpha) and lymphotoxin-beta (LT-beta), two related cytokines produced by lymphocytes and which are cytotoxic for a wide range of tumor cells in vitro and in vivo []. T cell antigen gp39 (CD40L), a cytokine which seems to be important in B-cell development and activation.CD27L, a cytokine which plays a role in T-cell activation. It induces the proliferation of costimulated T cells and enhances the generation of cytolytic T cells. CD30L, a cytokine which induces proliferation of T cells.FASL, a cytokine involved in cell death [].4-1BBL, a inducible T cell surface molecule that contributes to T-cell stimulation.OX40L, a cytokine that co-stimulates T cell proliferation and cytokine production [].TNF-related apoptosis inducing ligand (TRAIL), a cytokine that induces apoptosis [].TNF-alpha is synthesised as a type II membrane protein which then undergoes post-translational cleavage liberating the extracellular domain. CD27L, CD30L, CD40L, FASL, LT-beta, 4-1BBL and TRAIL also appear to be type II membrane proteins. LT-alpha is a secreted protein. All these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors. The PROSITE pattern for this family is located in a beta-strand in the central section of the protein which is conserved across all members.This entry represents Tumor Necrosis Factor, conserved site.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00251 PROSITE IPR021184

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

8 Found In

DB identifier Name Short Name Type
IPR008983 Tumour necrosis factor-like domain Tumour_necrosis_fac-like_dom Domain
IPR003263 Tumour necrosis factor ligand 5 TNF_ligand_5 Family
IPR017355 Tumour necrosis factor ligand 10/11 TNF_ligand_10/11 Family
IPR021185 Tumour necrosis factor family protein, CD30 ligand type TNF_CD30_ligand_type Family
IPR006053 Tumour necrosis factor TNF Family
IPR002960 Lymphotoxin-alpha TNF_beta Family
IPR002961 Lymphotoxin-beta TNF_C Family
IPR008064 Tumor necrosis factor ligand superfamily member 15 TNFSF15 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

9 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087494 Q8MY88 Drosophila melanogaster
FBpp0087493 Q8MUJ1 Drosophila melanogaster
FBpp0075833 Q9VTL1 Drosophila melanogaster
FBpp0168486 B4KNT8 Drosophila mojavensis
FBpp0236563 B4LJW9 Drosophila virilis
FBpp0264345 B4NX47 Drosophila yakuba
FBpp0266841 B4PFL6 Drosophila yakuba
Q8MRW2_DROME Q8MRW2 Drosophila melanogaster
Q8IGD3_DROME Q8IGD3 Drosophila melanogaster