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Protein Domain : IPR001102

Name  Transglutaminase, N-terminal Short Name  Transglutaminase_N
Type  Domain Description  Synonym(s): Protein-glutamine gamma-glutamyltransferase, Fibrinoligase, TGase Protein-glutamine gamma-glutamyltransferases () (TGase) are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines toproteins [, ].Transglutaminases are widely distributed in various organs, tissues andbody fluids. The best known transglutaminase is blood coagulation factor XIII,a plasma tetrameric protein composed of two catalytic A subunits and twonon-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilising the fibrin clot.There are commonly three domains: N-terminal, middle () and C-terminal (). This entry represents the N-terminal domain found in transglutaminases.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00868 PFAM IPR001102

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transglutaminase, N-terminal   GO:0018149 peptide cross-linking

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transglutaminase, N-terminal   GO:0018149 peptide cross-linking

1 Parent Features

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079156 Q8IPH0 Drosophila melanogaster
FBpp0079155 Q9VLU2 Drosophila melanogaster
FBpp0280740 Q29LV1 Drosophila pseudoobscura
FBpp0167130 B4KEB5 Drosophila mojavensis
FBpp0232101 B4LSK9 Drosophila virilis
FBpp0263735 B4NWC1 Drosophila yakuba
D0IQ93_DROME D0IQ93 Drosophila melanogaster