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Protein Domain : IPR020405

Name  Atypical dual specificity phosphatase, subfamily A Short Name  Atypical_DUSP_famA
Type  Family Description  Dual specificity phosphatases (DUSPs) are members of the superfamily of protein tyrosine phosphatases [, ]. They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. In general, DUSPs are classified into the following subgroups []:Slingshot phosphatasesPhosphatase of regenerating liver (PRL)Cdc14 phosphatasesPhosphatase and tensin homologue deleted on chromosome 10 (PTEN)-like and myotubularin phosphatasesMitogen-activated protein kinase phosphatases (MKPs)Atypical DUSPsThe atypical DUSPs share a highdegree of similarity with the MKP subgroup, but lack the N-terminal regulatory domain, which provides the substrate specificity towards the MAP kinases. These atypical-DUSPs form a heterogeneous group and have in common the presence of a single catalytic PTP domain. VHR was the first characterised member of this subfamily; its crystal structure is known [, ].The function of many atypical DUSPs remains unknown, although some have been related to regulation of MAP kinase pathways [, , ]. VHR has also been related to the control of cell-senescence []. The atypical DUSPs can be subdivided into two groups (termed A and B) on the basis of sequence similarity. Each of these subgroups is characterised by its own distinctive set of motifs, the functions of which are as yet unknown.This entry represents atypical dual specificity phosphatase subfamily A.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR016130 Protein-tyrosine phosphatase, active site Tyr_Pase_AS Active_site
IPR000340 Dual specificity phosphatase, catalytic domain Dual-sp_phosphatase_cat-dom Domain
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain Dual-sp_phosphatase_subgr_cat Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR01909 PRINTS IPR020405

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Atypical dual specificity phosphatase, subfamily A   GO:0008138 protein tyrosine/serine/threonine phosphatase activity
Atypical dual specificity phosphatase, subfamily A   GO:0006470 protein dephosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Atypical dual specificity phosphatase, subfamily A   GO:0008138 protein tyrosine/serine/threonine phosphatase activity
Atypical dual specificity phosphatase, subfamily A   GO:0006470 protein dephosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR020417 Atypical dual specificity phosphatase Atypical_DUSP Family

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074420 Q9VWN2 Drosophila melanogaster
FBpp0111917 A8JUQ2 Drosophila melanogaster
FBpp0274773 Q29GD4 Drosophila pseudoobscura
FBpp0164100 B4L4D0 Drosophila mojavensis
FBpp0229730 B4MCV2 Drosophila virilis
Q8SXF8_DROME Q8SXF8 Drosophila melanogaster
B4PWH4_DROYA B4PWH4 Drosophila yakuba