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Protein Domain : IPR018515

Name  Tuberin-type domain Short Name  Tuberin-type_domain
Type  Domain Description  Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit () and the small beta (). TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [].The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [].This domain is found in Tuberin proteins.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF03542 PFAM IPR018515

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR003913 Tuberin Tuberin Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tuberin-type domain   GO:0005096 GTPase activator activity
Tuberin-type domain   GO:0043547 positive regulation of GTPase activity

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tuberin-type domain   GO:0005096 GTPase activator activity
Tuberin-type domain   GO:0043547 positive regulation of GTPase activity

0 Parent Features

8 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074588 Q9VW83 Drosophila melanogaster
FBpp0304936 M9PD17 Drosophila melanogaster
FBpp0274936 Q2M0Y0 Drosophila pseudoobscura
FBpp0160740 B4KV88 Drosophila mojavensis
FBpp0225960 B4LG17 Drosophila virilis
FBpp0264656 B4PFT0 Drosophila yakuba
FBpp0267766 B4IUE9 Drosophila yakuba
Q9U9B0_DROME Q9U9B0 Drosophila melanogaster