modENCODE |  Help |  blog

Protein Domain : IPR008366

Name  Nuclear factor of activated T cells (NFAT) Short Name  NFAT
Type  Family Description  Antigenic stimulation of T lymphocytes initiates a complex series ofintracellular signal transduction pathways that leads to the expression of apanel of immunoregulatory genes, whose function is critical to theinitiation and coordination of the immune response. The multi-subunitnuclear factor of activated T cells (NFAT) transcription factor familyplays a pivotal role in this process and is involved in the expression of anumber of immunologically important genes. These include the cytokines IL-2,IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor, andtumour necrosis factor-alpha, as well as several cell-surface molecules,such as CD40L and FasL. Although originally described in T cells, it is nowapparent that NFAT proteins are also expressed in other immune system cells,including B cells, mast cells, basophils and natural killer cells, as wellas in a variety of non-immune cell types and tissues, such as skeletalmuscle, neurons, heart and adipocytes. However, although NFAT acts as acalcium-dependent transcription factor and serves to couple gene expressionto changes in intracellular calcium levels in most cases, NFAT target geneshave not been identified in these latter cell types.NFAT proteins appear to be regulated primarily at the level of theirsubcellular localisation []. They are found exclusively in the cytoplasm ofresting T cells, and consist of 2 components: a pre-existing cytoplasmiccomponent that translocates into the nucleus on calcium mobilisation, and aninducible nuclear component comprising members of the activating protein-1(AP-1) family of transcription factors. In response to antigen receptorsignalling, the calcium-regulated phosphatase calcineurin acts directly todephosphorylate NFAT proteins, causing their rapid translocation from thecytoplasm to the nucleus, where they cooperatively bind their target

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR002909 IPT domain IPT Domain
IPR011539 Rel homology domain RHD Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR12533 PANTHER IPR008366
PR01789 PRINTS IPR008366

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Nuclear factor of activated T cells (NFAT)   GO:0003700 sequence-specific DNA binding transcription factor activity
Nuclear factor of activated T cells (NFAT)   GO:0006355 regulation of transcription, DNA-templated

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Nuclear factor of activated T cells (NFAT)   GO:0003700 sequence-specific DNA binding transcription factor activity
Nuclear factor of activated T cells (NFAT)   GO:0006355 regulation of transcription, DNA-templated

0 Parent Features

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073639 Q9VYA6 Drosophila melanogaster
FBpp0309342 M9PH25 Drosophila melanogaster
FBpp0290665 Q9GU53 Drosophila melanogaster
FBpp0290666 E1JJP6 Drosophila melanogaster
FBpp0290664 E1JJP5 Drosophila melanogaster
FBpp0111893 A8JUV3 Drosophila melanogaster
FBpp0285490 Q29FM6 Drosophila pseudoobscura
FBpp0164294 B4L3B9 Drosophila mojavensis
FBpp0233301 B4M1B7 Drosophila virilis
FBpp0262104 B4Q2E1 Drosophila yakuba
Q86NT0_DROME Q86NT0 Drosophila melanogaster
A2VEY8_DROME A2VEY8 Drosophila melanogaster