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Protein Domain : IPR026712

Name  Choline/Ethanolamine kinase Short Name  Cho/Etha_kinase
Type  Family Description  The choline/ethanolamine kinase family includes choline kinase () and ethanolamine kinase ().Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment []. The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway [, ]. There are two putative choline/ethanolamine kinases (C/EKs) in the Trypanosoma bruceigenome. Besides catalysing the phosphorylation of choline to phosphorylcholine in the presence of ATP, choline kinase also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline. It may contribute to tumor cell growth in humans []. Ethanolamine kinase has no choline kinase activity []and its activity is inhibited by ADP []. Inositol supplementation represses ethanolamine kinase, decreasing the incorporation of ethanolamine into the CDP-ethanolamine pathway and into phosphatidylethanolamine and phosphatidylcholine [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR22603:SF32 PANTHER IPR026712

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Choline/Ethanolamine kinase   GO:0016301 kinase activity
Choline/Ethanolamine kinase   GO:0046474 glycerophospholipid biosynthetic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Choline/Ethanolamine kinase   GO:0016301 kinase activity
Choline/Ethanolamine kinase   GO:0046474 glycerophospholipid biosynthetic process

0 Parent Features

7 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0099951 Q2PDP3 Drosophila melanogaster
FBpp0085276 Q8IMF3 Drosophila melanogaster
FBpp0085277 Q8IMF4 Drosophila melanogaster
FBpp0085275 Q9V9R4 Drosophila melanogaster
FBpp0161371 B4KF17 Drosophila mojavensis
FBpp0228621 B4LUP6 Drosophila virilis
Q95RP0_DROME Q95RP0 Drosophila melanogaster