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Protein Domain : IPR011539

Name  Rel homology domain Short Name  RHD
Type  Domain Description  The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. Some of these transcription factors appear to form multi-protein DNA-bound complexes []. Phosphorylation of the RHD appears to play a role in the regulation of some of these transcription factors, acting to modulate the expression of their target genes []. The RHD is composed of two immunoglobulin-like beta-barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases; the C-terminal dimerisationdomain contains the site for interaction with I-kappaB [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00554 PFAM IPR011539
PS50254 PROFILE IPR011539
G3DSA:2.60.40.340 GENE3D IPR011539

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR000451 NF-kappa-B/Rel/Dorsal NF_Rel_Dor Family
IPR011363 Dorsal protein Dorsal Family
IPR008366 Nuclear factor of activated T cells (NFAT) NFAT Family
IPR015646 Nuclear factor of activated T-cells 5 NFAT5 Family
IPR015647 Nuclear factor of activated T-cells 1 NFAT1 Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Rel homology domain   GO:0003700 sequence-specific DNA binding transcription factor activity
Rel homology domain   GO:0006355 regulation of transcription, DNA-templated
Rel homology domain   GO:0005634 nucleus

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Rel homology domain   GO:0003700 sequence-specific DNA binding transcription factor activity
Rel homology domain   GO:0006355 regulation of transcription, DNA-templated
Rel homology domain   GO:0005634 nucleus

1 Parent Features

DB identifier Name Short Name Type
IPR008967 p53-like transcription factor, DNA-binding p53-like_TF_DNA-bd Domain

31 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0290793 P98149 Drosophila melanogaster
FBpp0080559 E1JHK3 Drosophila melanogaster
FBpp0080560 P15330 Drosophila melanogaster
FBpp0290792 E1JHK2 Drosophila melanogaster
FBpp0088375 Q94527 Drosophila melanogaster
FBpp0073639 Q9VYA6 Drosophila melanogaster
FBpp0309342 M9PH25 Drosophila melanogaster
FBpp0290665 Q9GU53 Drosophila melanogaster
FBpp0290666 E1JJP6 Drosophila melanogaster
FBpp0290664 E1JJP5 Drosophila melanogaster
FBpp0111893 A8JUV3 Drosophila melanogaster
FBpp0285490 Q29FM6 Drosophila pseudoobscura
FBpp0280065 Q29MR1 Drosophila pseudoobscura
FBpp0280062 Q29MQ9 Drosophila pseudoobscura
FBpp0284786 Q294I3 Drosophila pseudoobscura
FBpp0159410 B4KBY7 Drosophila mojavensis
FBpp0164294 B4L3B9 Drosophila mojavensis
FBpp0165758 B4KFR3 Drosophila mojavensis
FBpp0165769 B4KFR5 Drosophila mojavensis
FBpp0230649 B4MDE2 Drosophila virilis
FBpp0230650 B4MDE4 Drosophila virilis
FBpp0233301 B4M1B7 Drosophila virilis
FBpp0237898 B4LX50 Drosophila virilis
FBpp0258146 B4P8S0 Drosophila yakuba
FBpp0258148 B4P8S3 Drosophila yakuba
FBpp0262104 B4Q2E1 Drosophila yakuba
FBpp0269810 B4PTZ8 Drosophila yakuba
DORS_DROME-2 P15330-2 Drosophila melanogaster
NFKB1_DROME-2 Q94527-2 Drosophila melanogaster
Q86NT0_DROME Q86NT0 Drosophila melanogaster