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Protein Domain : IPR008606

Name  Eukaryotic translation initiation factor 4E binding Short Name  EIF4EBP
Type  Family Description  This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1, -2 and -3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF05456 PFAM IPR008606

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Eukaryotic translation initiation factor 4E binding   GO:0008190 eukaryotic initiation factor 4E binding
Eukaryotic translation initiation factor 4E binding   GO:0045947 negative regulation of translational initiation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Eukaryotic translation initiation factor 4E binding   GO:0008190 eukaryotic initiation factor 4E binding
Eukaryotic translation initiation factor 4E binding   GO:0045947 negative regulation of translational initiation

0 Parent Features

6 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0077213 Q9XZ56 Drosophila melanogaster
FBpp0279961 Q29MC3 Drosophila pseudoobscura
FBpp0164213 B4KHH5 Drosophila mojavensis
FBpp0164224 B4KHH4 Drosophila mojavensis
FBpp0231655 B4LU44 Drosophila virilis
FBpp0263249 B4NXX5 Drosophila yakuba