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Protein Domain : IPR002011

Name  Tyrosine-protein kinase, receptor class II, conserved site Short Name  Tyr_kinase_rcpt_2_CS
Type  Conserved_site Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].A number of growth factors stimulate mitogenesis by interacting with a familyof cell surface receptors which possess an intrinsic, ligand-sensitive,protein tyrosine kinase activity []. These receptor tyrosine kinases (RTK)all share the same topology: an extracellular ligand-binding domain, a singletransmembrane region and a cytoplasmic kinase domain. However they can beclassified into at least five groups. The prototype for class II RTK's is theinsulin receptor, a heterotetramer of two alpha and two beta chains linked bydisulphide bonds. The alpha and beta chains are cleavage products of aprecursor molecule. The alpha chain contains the ligand binding site, the betachain transverses the membrane and contains the tyrosine protein kinasedomain.While only the insulin and the insulin growth factor I receptors are known toexist in the tetrameric conformation specific to class II RTK's, all the aboveproteins share extensive homologies in their kinase domain, especially aroundthe putative site of autophosphorylation.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00239 PROSITE IPR002011

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

9 Found In

DB identifier Name Short Name Type
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain Ser-Thr/Tyr_kinase_cat_dom Domain
IPR020635 Tyrosine-protein kinase, catalytic domain Tyr_kinase_cat_dom Domain
IPR016246 Tyrosine-protein kinase, insulin-like receptor Tyr_kinase_insulin-like_rcpt Family
IPR020777 Tyrosine-protein kinase, neurotrophic receptor Tyr_kinase_NGF_rcpt Family
IPR020446 Tyrosine-protein kinase, neurotrophic receptor, type 3 Tyr_kin_neurotrophic_rcpt_3 Family
IPR020455 Tyrosine-protein kinase, neurotrophic receptor, type 2 Tyr_kin_neurotrophic_rcpt_2 Family
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1 Tyr_kinase_neurotrophic_rcpt_1 Family

5 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, receptor class II, conserved site   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, receptor class II, conserved site   GO:0005524 ATP binding
Tyrosine-protein kinase, receptor class II, conserved site   GO:0006468 protein phosphorylation
Tyrosine-protein kinase, receptor class II, conserved site   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Tyrosine-protein kinase, receptor class II, conserved site   GO:0016020 membrane

5 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tyrosine-protein kinase, receptor class II, conserved site   GO:0004714 transmembrane receptor protein tyrosine kinase activity
Tyrosine-protein kinase, receptor class II, conserved site   GO:0005524 ATP binding
Tyrosine-protein kinase, receptor class II, conserved site   GO:0006468 protein phosphorylation
Tyrosine-protein kinase, receptor class II, conserved site   GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Tyrosine-protein kinase, receptor class II, conserved site   GO:0016020 membrane

0 Parent Features

28 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086264 Q7KJ08 Drosophila melanogaster
FBpp0079568 Q24488 Drosophila melanogaster
FBpp0083519 P09208 Drosophila melanogaster
FBpp0278795 Q28WN9 Drosophila pseudoobscura
FBpp0284578 Q29HZ3 Drosophila pseudoobscura
FBpp0300775 B5DYR5 Drosophila pseudoobscura
FBpp0165676 B4L714 Drosophila mojavensis
FBpp0167713 B4KSN1 Drosophila mojavensis
FBpp0168392 B4KJH7 Drosophila mojavensis
FBpp0230353 B4MAM2 Drosophila virilis
FBpp0232526 B4M8G9 Drosophila virilis
FBpp0235776 B4LPA2 Drosophila virilis
FBpp0237711 B4LZ52 Drosophila virilis
FBpp0259059 B4P5X8 Drosophila yakuba
FBpp0262333 B4PYU8 Drosophila yakuba
FBpp0263921 B4NZ73 Drosophila yakuba
FBpp0269980 B4PQW4 Drosophila yakuba
7LESS_DROVI P20806 Drosophila virilis
7LESS_DROME P13368 Drosophila melanogaster
Q8SWV4_DROME Q8SWV4 Drosophila melanogaster
C7C416_DROME C7C416 Drosophila melanogaster
C7C412_DROME C7C412 Drosophila melanogaster
C7C417_DROME C7C417 Drosophila melanogaster
C7C410_DROME C7C410 Drosophila melanogaster
C7C411_DROME C7C411 Drosophila melanogaster
C7C415_DROME C7C415 Drosophila melanogaster
C7C414_DROME C7C414 Drosophila melanogaster
C7C413_DROME C7C413 Drosophila melanogaster