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Protein Domain : IPR018350

Name  Transcription factor COE, conserved site Short Name  Transcription_factor_COE_CS
Type  Conserved_site Description  The independent cloning of rodent EBF/Olf-1 and Drosophila melanogasterCollier has defineda family of transcription factors, the Collier or COE family []. COE proteinshave various functions in different organisms. In mouse, COE1 has a role in B-cell differentiation, and could also perform arole in neuronal differentiation. All three COE are expressed in immatureolfactory neuronal precursors and mature olfactory neurons as well as indevelopping nervous system during embryogenesis.In Drosophila, Collier is involved in the formation of the embryonic somaticmuscle DA3, in the patterning of the wing by mediating Hedgehog activity.It could also act as a second-level regulator in the patterning of embryonichead. This conserved region is located in a domain thought to be part of the DNA-binding region. The signature includes four conserved cysteines that could be part of a zinc-finger motif.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS01345 PROSITE IPR018350

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

1 Found In

DB identifier Name Short Name Type
IPR003523 Transcription factor COE Transcription_factor_COE Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

13 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086595 V5LWW0 Drosophila melanogaster
FBpp0111721 P56721 Drosophila melanogaster
FBpp0290614 A1Z9V2 Drosophila melanogaster
FBpp0111722 A8DYD9 Drosophila melanogaster
FBpp0276815 B5E039 Drosophila pseudoobscura
FBpp0170239 B4KQX3 Drosophila mojavensis
FBpp0236362 B4LPT7 Drosophila virilis
FBpp0257296 B4P7P4 Drosophila yakuba
A8X4H7_CAEBR A8X4H7 Caenorhabditis briggsae
G0MB66_CAEBE G0MB66 Caenorhabditis brenneri
UNC3_CAEEL Q93705 Caenorhabditis elegans
COLL_DROME-2 P56721-2 Drosophila melanogaster
E3MC54_CAERE E3MC54 Caenorhabditis remanei