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Protein Domain : IPR011576

Name  Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain Short Name  Pyridox_Oxase_FMN-bd
Type  Domain Description  Pyridoxamine 5'-phosphate oxidase (PNPOx; ) is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This reaction serves as the terminal step in the de novo biosynthesis of PLP in Escherichia coli and as a part of the salvage pathway of this coenzyme in both E. coli and mammalian cells [, ]. The binding sites for FMN and for substrate have been highly conserved throughout evolution.This entry represents the FMN-binding domain present in pyridoxamine 5'-phosphate oxidases, as well as in a number of proteins that have not been demonstrated to have enzymatic activity. The FMN-binding domain has a structure consisting of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. PNPOx has a different dimerisation mode than that found in flavin reductases, which also carry an FMN-binding domain with a similar topology.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF01243 PFAM IPR011576

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

9 Found In

DB identifier Name Short Name Type
IPR000659 Pyridoxamine 5'-phosphate oxidase Pyridox_Oxase Family
IPR012349 FMN-binding split barrel Split_barrel_FMN-bd Domain
IPR021198 Pyridoxamine 5'-phosphate oxidase, plant Pyridox_Oxase_pln Family
IPR019920 F420-binding domain, putative F420-binding_dom_put Domain
IPR019965 PPOX class F420-dependent enzyme, family Rv2061, putative PPOX_F420-dep_Rv2061_put Family
IPR019967 F420-dependent enzyme, PPOX class, family Rv0121, probable F420-dep_enz_PPOX_Rv0121 Family
IPR019966 F420-dependent enzyme, PPOX class, family Rv3369, probable F420-dep_enz_PPOX_Rv3369 Family
IPR014419 Heme utilization protein with pyridoxamine 5'-phosphate domain Heme_util_pro_pyrio5phos_dom Family
IPR014599 Haem iron utilisation protein, pyridoxamine 5'-phosphate domain-type Haem-Fe_utiliz_PLP-type Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain   GO:0004733 pyridoxamine-phosphate oxidase activity
Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain   GO:0010181 FMN binding
Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain   GO:0055114 oxidation-reduction process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain   GO:0004733 pyridoxamine-phosphate oxidase activity
Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain   GO:0010181 FMN binding
Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain   GO:0055114 oxidation-reduction process

0 Parent Features

22 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081244 Q9VHZ5 Drosophila melanogaster
FBpp0081245 Q7KSW3 Drosophila melanogaster
FBpp0071126 Q9W3G8 Drosophila melanogaster
FBpp0081246 Q8INR5 Drosophila melanogaster
FBpp0284758 B5DWG8 Drosophila pseudoobscura
FBpp0284759 Q294M0 Drosophila pseudoobscura
FBpp0286416 Q29HS1 Drosophila pseudoobscura
FBpp0165083 B4L1L9 Drosophila mojavensis
FBpp0173348 B4K6T6 Drosophila mojavensis
FBpp0173349 B4K6T7 Drosophila mojavensis
FBpp0225371 B4M4K5 Drosophila virilis
FBpp0225372 B4M4K6 Drosophila virilis
FBpp0233441 B4M347 Drosophila virilis
FBpp0256197 B4IUW1 Drosophila yakuba
FBpp0256198 B4IUW2 Drosophila yakuba
FBpp0262473 B4Q0D0 Drosophila yakuba
FBpp0269953 B4PRE5 Drosophila yakuba
A8XPB7_CAEBR A8XPB7 Caenorhabditis briggsae
A8XJM7_CAEBR A8XJM7 Caenorhabditis briggsae
G0MES3_CAEBE G0MES3 Caenorhabditis brenneri
PDXH_CAEEL Q20939 Caenorhabditis elegans
E3MCI3_CAERE E3MCI3 Caenorhabditis remanei