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Protein Domain : IPR000659

Name  Pyridoxamine 5'-phosphate oxidase Short Name  Pyridox_Oxase
Type  Family Description  Pyridoxamine 5'-phosphate oxidase () is an enzyme that is involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The enzyme requires the presence of flavin mononucleotide (FMN) as a cofactor, although there is some evidence that coenzyme F420 may perform this role in some species [].The sequences of the enzyme from bacterial (genes pdxH or fprA) []andfungal (gene PDX3) []sources show that this protein has been highly conserved throughout evolution. PdxH is evolutionary related []to one of the enzymes in the phenazine biosynthesis protein pathway, phzD (also known as phzG).

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR019740 Pyridoxamine 5'-phosphate oxidase, conserved site Pyridox_Oxase_CS Conserved_site
IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain Pyridox_Oxase_FMN-bd Domain
IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal Pyridoxamine_oxidase_dimer_C Domain
IPR012349 FMN-binding split barrel Split_barrel_FMN-bd Domain

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR10851 PANTHER IPR000659
PIRSF000190 PIRSF IPR000659
TIGR00558 TIGRFAMs IPR000659
MF_01629 HAMAP IPR000659

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxamine 5'-phosphate oxidase   GO:0004733 pyridoxamine-phosphate oxidase activity
Pyridoxamine 5'-phosphate oxidase   GO:0008615 pyridoxine biosynthetic process
Pyridoxamine 5'-phosphate oxidase   GO:0055114 oxidation-reduction process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxamine 5'-phosphate oxidase   GO:0004733 pyridoxamine-phosphate oxidase activity
Pyridoxamine 5'-phosphate oxidase   GO:0008615 pyridoxine biosynthetic process
Pyridoxamine 5'-phosphate oxidase   GO:0055114 oxidation-reduction process

0 Parent Features

23 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081244 Q9VHZ5 Drosophila melanogaster
FBpp0081245 Q7KSW3 Drosophila melanogaster
FBpp0071126 Q9W3G8 Drosophila melanogaster
FBpp0081246 Q8INR5 Drosophila melanogaster
FBpp0284758 B5DWG8 Drosophila pseudoobscura
FBpp0284759 Q294M0 Drosophila pseudoobscura
FBpp0286416 Q29HS1 Drosophila pseudoobscura
FBpp0165083 B4L1L9 Drosophila mojavensis
FBpp0173348 B4K6T6 Drosophila mojavensis
FBpp0173349 B4K6T7 Drosophila mojavensis
FBpp0225371 B4M4K5 Drosophila virilis
FBpp0225372 B4M4K6 Drosophila virilis
FBpp0233441 B4M347 Drosophila virilis
FBpp0256197 B4IUW1 Drosophila yakuba
FBpp0256198 B4IUW2 Drosophila yakuba
FBpp0262473 B4Q0D0 Drosophila yakuba
FBpp0269953 B4PRE5 Drosophila yakuba
A8XPB7_CAEBR A8XPB7 Caenorhabditis briggsae
A8XJM7_CAEBR A8XJM7 Caenorhabditis briggsae
K7II29_CAEJA K7II29 Caenorhabditis japonica
G0MES3_CAEBE G0MES3 Caenorhabditis brenneri
PDXH_CAEEL Q20939 Caenorhabditis elegans
E3MCI3_CAERE E3MCI3 Caenorhabditis remanei