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Protein Domain : IPR014048

Name  Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding Short Name  MethylDNA_cys_MeTrfase_DNA-bd
Type  Domain Description  Synonym(s): 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferaseThis entry represents the DNA binding region of 6-O-methylguanine-DNA methyltransferases.The repair of DNA containing O6-alkylatedguanine is carried out by DNA-[protein]-cysteine S-methyltransferase (). The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine. Thealkyl group at the O-6 position is transferred to a cysteine residue in theenzyme []. This is a suicide reaction since the enzyme is irreversibly inactivatedand the methylated protein accumulates as a dead-end product. Most, but notall of the methyltransferases are also able to repair O-4-methylthymine. DNA-[protein]-cysteine S-methyltransferases are widely distributed and are found in various prokaryotic and eukaryotic sources [].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site MethylDNA_cys_MeTrfase_AS Active_site

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF01035 PFAM IPR014048
TIGR00589 TIGRFAMs IPR014048
SSF46767 SSF IPR014048

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR016221 Bifunctional regulatory protein Ada Bifunct_regulatory_prot_Ada Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding   GO:0003824 catalytic activity
Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding   GO:0006281 DNA repair

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding   GO:0003824 catalytic activity
Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding   GO:0006281 DNA repair

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

13 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081195 O76339 Drosophila melanogaster
FBpp0284311 Q296T7 Drosophila pseudoobscura
FBpp0172978 B4KBK1 Drosophila mojavensis
FBpp0238362 B4LZ45 Drosophila virilis
FBpp0270850 B4PSK0 Drosophila yakuba
A8WQU4_CAEBR A8WQU4 Caenorhabditis briggsae
H2VX09_CAEJA H2VX09 Caenorhabditis japonica
G0NTG3_CAEBE G0NTG3 Caenorhabditis brenneri
Q9U1Y0_CAEEL Q9U1Y0 Caenorhabditis elegans
Q2HQK2_CAEEL Q2HQK2 Caenorhabditis elegans
E3M690_CAERE E3M690 Caenorhabditis remanei
E3NVI7_CAERE E3NVI7 Caenorhabditis remanei
E3NWH4_CAERE E3NWH4 Caenorhabditis remanei