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Protein Domain : IPR003150

Name  DNA-binding RFX-type winged-helix domain Short Name  DNA-bd_RFX
Type  Domain Description  The RFX family of transcription factors is characterised by a unique approximately 75-residue DNA-binding domain. RFX genes have been isolated in yeasts, nematode and vertebrates. The characteristic RFX-type HTH DNA binding domain has been recruited into otherwise very divergent regulatory factors functioning in a diverse spectrum of unrelated systems, including regulation of the mitotic cell cycle in fission yeast, the control of the immune response in mammals,and infection by human hepatitis B virus [, ]. The RFX-type DNA-binding domain is an unusual member of the winged-helixsubfamily of helix-turn-helix domains because it uses a beta-hairpin (or wing)to recognise DNA instead of the recognition helix typical of helix-tun-helixdomains. It consists of three alpha-helices (H), three beta-strands (S) andthree connecting loops (L), arranged in the order H1-S1-H2-L1-H3-L2-S2-W1-S3.The third loop, connecting beta-strands S2 and S3, forms wing W1 of thewinged-helix motif. In contrast to previously describedwinged-helix DBDs (typically 110 residues long with two wings, W1 and W2), theshorter RFX-type winged-helix DNA-binding domain has only one wing [].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF02257 PFAM IPR003150
PS51526 PROFILE IPR003150

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
DNA-binding RFX-type winged-helix domain   GO:0003677 DNA binding
DNA-binding RFX-type winged-helix domain   GO:0006355 regulation of transcription, DNA-templated

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
DNA-binding RFX-type winged-helix domain   GO:0003677 DNA binding
DNA-binding RFX-type winged-helix domain   GO:0006355 regulation of transcription, DNA-templated

1 Parent Features

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

37 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085442 A1Z6M0 Drosophila melanogaster
FBpp0081227 Q9VI23 Drosophila melanogaster
FBpp0308021 Q9VGZ6 Drosophila melanogaster
FBpp0275815 Q28WX3 Drosophila pseudoobscura
FBpp0293639 I5ANB0 Drosophila pseudoobscura
FBpp0283527 Q29AL6 Drosophila pseudoobscura
FBpp0293640 I5ANB1 Drosophila pseudoobscura
FBpp0300479 Q296S5 Drosophila pseudoobscura
FBpp0167597 B4KUH1 Drosophila mojavensis
FBpp0173247 B4K529 Drosophila mojavensis
FBpp0173800 B4K4N6 Drosophila mojavensis
FBpp0235874 B4LIM8 Drosophila virilis
FBpp0237067 B4LZS5 Drosophila virilis
FBpp0238076 B4LW48 Drosophila virilis
FBpp0264071 B4P0Y3 Drosophila yakuba
FBpp0269109 B4PKS6 Drosophila yakuba
FBpp0269699 B4PKP5 Drosophila yakuba
B0K060_CAEBR B0K060 Caenorhabditis briggsae
A8XHZ2_CAEBR A8XHZ2 Caenorhabditis briggsae
K7GVN6_CAEJA K7GVN6 Caenorhabditis japonica
K7GVN5_CAEJA K7GVN5 Caenorhabditis japonica
K7IH72_CAEJA K7IH72 Caenorhabditis japonica
G0NLS2_CAEBE G0NLS2 Caenorhabditis brenneri
G0PAN8_CAEBE G0PAN8 Caenorhabditis brenneri
DAF19_CAEEL Q09555 Caenorhabditis elegans
DAF19_CAEEL-2 Q09555-2 Caenorhabditis elegans
SWSN7_CAEEL Q09441 Caenorhabditis elegans
G5EBW8_CAEEL G5EBW8 Caenorhabditis elegans
S6EZR7_CAEEL S6EZR7 Caenorhabditis elegans
C0P280_CAEEL C0P280 Caenorhabditis elegans