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Protein Domain : IPR002853

Name  Transcription factor TFIIE, alpha subunit Short Name  TFIIE_asu
Type  Family Description  Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit () and the small beta (). TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [].The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [].This entry represents the conserved amino terminal region of eukaryotic TFIIE-alpha and proteins from archaebacteria (TFE) that are also presumed to be TFIIE-alpha subunits [].

Publication Counts Displayer

0 Child Features

3 Contains

DB identifier Name Short Name Type
IPR013083 Zinc finger, RING/FYVE/PHD-type Znf_RING/FYVE/PHD Domain
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR017919 Transcription factor TFE/TFIIEalpha HTH domain TFIIE/TFIIEa_HTH Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SM00531 SMART IPR002853

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor TFIIE, alpha subunit   GO:0006367 transcription initiation from RNA polymerase II promoter

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription factor TFIIE, alpha subunit   GO:0006367 transcription initiation from RNA polymerase II promoter

0 Parent Features

9 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075839 O96880 Drosophila melanogaster
FBpp0274182 Q2LZ72 Drosophila pseudoobscura
FBpp0162934 B4KUS0 Drosophila mojavensis
FBpp0228477 B4LCQ5 Drosophila virilis
FBpp0266846 B4PFM4 Drosophila yakuba
A8WMX3_CAEBR A8WMX3 Caenorhabditis briggsae
G0MRB8_CAEBE G0MRB8 Caenorhabditis brenneri
G5EG49_CAEEL G5EG49 Caenorhabditis elegans
E3NBB7_CAERE E3NBB7 Caenorhabditis remanei