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Protein Domain : IPR024792

Name  Rho GDP-dissociation inhibitor domain Short Name  RhoGDI_domain
Type  Domain Description  The GDP dissociation inhibitor for rho proteins, rho GDI, regulates GDP/GTPexchange by inhibiting the dissociation of GDP from them. The protein contains 204 amino acids, with a calculated Mr valueof 23,421. Hydropathy analysis shows it to be largely hydrophilic, with asingle hydrophobic region. Results of database searches suggest rho GDI isa novel protein, currently with no known homologue. The protein plays an important role in the activation of the superoxide(O2-)-generating NADPH oxidase of phagocytes. This process requires theinteraction of membrane-associated cytochrome b559 with 3 cytosoliccomponents: p47-phox, p67-phox and a heterodimer of the small G-proteinp21rac1 and rho GDI []. The association of p21rac and GDI inhibitsdissociation of GDP from p21rac, thereby maintaining it in an inactive form.The proteins are attached via a lipid tail on p21rac that binds to thehydrophobic region of GDI []. Dissociation of these proteins might bemediated by the release of lipids (e.g., arachidonate and phosphatidate)from membranes through the action of phospholipases []. The lipids may thencompete with the lipid tail on p21rac for the hydrophobic pocket on GDI.The rhoGDI structural domain contains both a structured, immunoglobulin-like fold, and a highly flexible N terminus of 50-60 residues []. The N-terminal region becomes ordered upon complex formation and contributes more than 60% to the interface area [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR014756 Immunoglobulin E-set Ig_E-set Domain

14 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074665 Q9VW59 Drosophila melanogaster
FBpp0274057 Q2LYW1 Drosophila pseudoobscura
FBpp0160871 B4L0V7 Drosophila mojavensis
FBpp0225751 B4LBK9 Drosophila virilis
FBpp0264647 B4PFV8 Drosophila yakuba
FBpp0268232 B4IUD7 Drosophila yakuba
A8XK11_CAEBR A8XK11 Caenorhabditis briggsae
B6IJD6_CAEBR B6IJD6 Caenorhabditis briggsae
H2VR50_CAEJA H2VR50 Caenorhabditis japonica
G0M848_CAEBE G0M848 Caenorhabditis brenneri
G0M7W9_CAEBE G0M7W9 Caenorhabditis brenneri
GDIR_CAEEL Q20496 Caenorhabditis elegans
Q9TY60_CAEEL Q9TY60 Caenorhabditis elegans
E3LEG3_CAERE E3LEG3 Caenorhabditis remanei