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Protein Domain : IPR016656

Name  Transcription initiation factor TFIIE, beta subunit Short Name  TFIIE-bsu
Type  Family Description  Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit () and the small beta (). TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [].The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [].This group represents a transcription initiation factor TFIIE, beta subunit.

Publication Counts Displayer

0 Child Features

2 Contains

DB identifier Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR003166 Transcription factor TFIIE beta subunit, DNA-binding domain TFIIE_bsu_DNA-bd Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF016398 PIRSF IPR016656

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription initiation factor TFIIE, beta subunit   GO:0006367 transcription initiation from RNA polymerase II promoter
Transcription initiation factor TFIIE, beta subunit   GO:0005673 transcription factor TFIIE complex

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Transcription initiation factor TFIIE, beta subunit   GO:0006367 transcription initiation from RNA polymerase II promoter
Transcription initiation factor TFIIE, beta subunit   GO:0005673 transcription factor TFIIE complex

0 Parent Features

11 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073090 O96881 Drosophila melanogaster
FBpp0289677 E1JIC9 Drosophila melanogaster
FBpp0286773 Q29EG4 Drosophila pseudoobscura
FBpp0165810 B4L9A3 Drosophila mojavensis
FBpp0227262 B4LBQ9 Drosophila virilis
FBpp0266446 B4PHT7 Drosophila yakuba
A8WTC4_CAEBR A8WTC4 Caenorhabditis briggsae
H2VS50_CAEJA H2VS50 Caenorhabditis japonica
G0MV65_CAEBE G0MV65 Caenorhabditis brenneri
G5EG47_CAEEL G5EG47 Caenorhabditis elegans
E3LF66_CAERE E3LF66 Caenorhabditis remanei